Targeted replacement of the mycocerosic acid synthase gene in Mycobacterium bovis BCG produces a mutant that lacks mycosides.
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Interaction between polyketide synthase and transporter suggests coupled synthesis and export of virulence lipid in M. tuberculosis.Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosisGene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteriaRole of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameCloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosisDisruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: effect on growth in culture and in macrophagesp-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosisThe Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesisDisruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregationOpen reading frame 3, which is adjacent to the mycocerosic acid synthase gene, is expressed as an acyl coenzyme A synthase in Mycobacterium bovis BCGAttenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesisMycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acidsCharacterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complexAttenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosisAnalysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrierMolecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complexThe largest open reading frame (pks12) in the Mycobacterium tuberculosis genome is involved in pathogenesis and dimycocerosyl phthiocerol synthesis.Site-directed mutagenesis of the 19-kilodalton lipoprotein antigen reveals No essential role for the protein in the growth and virulence of Mycobacterium intracellulareIdentification of phthiodiolone ketoreductase, an enzyme required for production of mycobacterial diacyl phthiocerol virulence factorsComparative genomics of cell envelope components in mycobacteria.Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guérin, and Mycobacterium tuberculosis H37Rv by allelic exchange.Assessing the Genotypic Differences between Strains of Corynebacterium pseudotuberculosis biovar equi through Comparative Genomics.Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids.Characterization of a novel heat shock protein (Hsp22.5) involved in the pathogenesis of Mycobacterium tuberculosis.A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organismsBiosynthesis of diaminopimelate, the precursor of lysine and a component of peptidoglycan, is an essential function of Mycobacterium smegmatis.Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.Both phthiocerol dimycocerosates and phenolic glycolipids are required for virulence of Mycobacterium marinum.Defining mycobacteria: Shared and specific genome features for different lifestylesDemonstration of allelic exchange in the slow-growing bacterium Mycobacterium avium subsp. paratuberculosis, and generation of mutants with deletions at the pknG, relA, and lsr2 loci.Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis.Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis.Pleiotropic consequences of gene knockouts in the phthiocerol dimycocerosate and phenolic glycolipid biosynthetic gene cluster of the opportunistic human pathogen Mycobacterium marinumDisruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis.Subtractive hybridization reveals a type I polyketide synthase locus specific to Mycobacterium ulcerans.F420H2 Is Required for Phthiocerol Dimycocerosate Synthesis in Mycobacteria.Biosynthesis of mycobacterial lipids by polyketide synthases and beyond.iniBAC induction Is Vitamin B12- and MutAB-dependent in Mycobacterium marinumRapid and spontaneous loss of phthiocerol dimycocerosate (PDIM) from Mycobacterium tuberculosis grown in vitro: implications for virulence studies.
P2860
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P2860
Targeted replacement of the mycocerosic acid synthase gene in Mycobacterium bovis BCG produces a mutant that lacks mycosides.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1996
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Targeted replacement of the my ...... a mutant that lacks mycosides.
@en
Targeted replacement of the my ...... a mutant that lacks mycosides.
@nl
type
label
Targeted replacement of the my ...... a mutant that lacks mycosides.
@en
Targeted replacement of the my ...... a mutant that lacks mycosides.
@nl
prefLabel
Targeted replacement of the my ...... a mutant that lacks mycosides.
@en
Targeted replacement of the my ...... a mutant that lacks mycosides.
@nl
P2093
P2860
P356
P1476
Targeted replacement of the my ...... a mutant that lacks mycosides.
@en
P2093
L M Rogers
P E Kolattukudy
T D Sirakova
P2860
P304
P356
10.1073/PNAS.93.10.4787
P407
P577
1996-05-01T00:00:00Z