Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.
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Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosisThe product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent mannerA novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytesCbl-ArgBP2 complex mediates ubiquitination and degradation of c-AblStructural basis for autoinhibition and phosphorylation-dependent activation of c-CblPhosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicityWiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domainsThe role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancerProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesMutant Cbl proteins as oncogenic drivers in myeloproliferative disordersThe ubiquitin-proteasome pathway and proteasome inhibitorsAssociation of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytesCasitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformationThe kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylationThe Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development.c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts.The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells.c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGFc-Cbl-mediated regulation of LAT-nucleated signaling complexesCbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding.The UPS in diabetes and obesity.Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceThe phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradationCbl and human myeloid neoplasms: the Cbl oncogene comes of age.The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolismEnhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversionNovel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemiac-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signalingLyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.High c-Cbl expression in gliomas is associated with tumor progression and poor prognosisRapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and CblA chimeric receptor/oncogene that can be regulated by a ligand in vitro and in vivoStructural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.
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P2860
Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1994
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Tumour induction by activated ...... e product of the cbl oncogene.
@en
Tumour induction by activated ...... e product of the cbl oncogene.
@nl
type
label
Tumour induction by activated ...... e product of the cbl oncogene.
@en
Tumour induction by activated ...... e product of the cbl oncogene.
@nl
prefLabel
Tumour induction by activated ...... e product of the cbl oncogene.
@en
Tumour induction by activated ...... e product of the cbl oncogene.
@nl
P2093
P2860
P1433
P1476
Tumour induction by activated ...... e product of the cbl oncogene.
@en
P2093
C E Andoniou
W Y Langdon
P2860
P304
P407
P577
1994-10-01T00:00:00Z