Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. - Wikidata - wikimedia - TriplyDB

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

http://www.wikidata.org/entity/Q37659122

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A feline model of experimentally induced islet amyloidosis The Rationale for Insulin Therapy in Alzheimer's Disease On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice Heparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complications Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation.Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts.Minireview: Estrogenic protection of beta-cell failure in metabolic diseases.The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer's disease.Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation.Endocrine amyloid--a subject of increasing interest for the next century.Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation.Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.TNF-α acutely upregulates amylin expression in murine pancreatic beta cells.Factors associated with beta-cell dysfunction in type 2 diabetes: the BETADECLINE study.Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity.Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.Type 2 diabetes and the aging pancreatic beta cell.Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity.Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.Glucose- and time-dependence of islet amyloid formation in vitro.Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro Cerebral lipid deposition in aged apolipoprotein-E-deficient mice.Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets Determination of Optimal Sample Size for Quantification of β-Cell Area, Amyloid Area and β-Cell Apoptosis in Isolated Islets Pancreatic function, type 2 diabetes, and metabolism in aging.Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity Feline models of type 2 diabetes mellitus.Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.Disturbed alpha-cell function in mice with beta-cell specific overexpression of human islet amyloid polypeptide Islet β cell mass in diabetes and how it relates to function, birth, and death.Is Glucagon-like peptide-1, an agent treating diabetes, a new hope for Alzheimer's disease?Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.

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Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

http://www.wikidata.org/entity/Q37659122

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on April 1996

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Islet amyloid formation associ ...... man islet amyloid polypeptide.

@en

Islet amyloid formation associ ...... man islet amyloid polypeptide.

@nl

type

label

Islet amyloid formation associ ...... man islet amyloid polypeptide.

@en

Islet amyloid formation associ ...... man islet amyloid polypeptide.

@nl

prefLabel

Islet amyloid formation associ ...... man islet amyloid polypeptide.

@en

Islet amyloid formation associ ...... man islet amyloid polypeptide.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Islet amyloid formation associ ...... uman islet amyloid polypeptide

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C B Verchere

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D A D'Alessio

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D G Baskin

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G C Weir

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R D Palmiter

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S Bonner-Weir

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P2860

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue.

Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia.

Localisation of islet amyloid peptide in lipofuscin bodies and secretory granules of human B-cells and in islets of type-2 diabetic subjects.

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques.

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3492-3496

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10.1073/PNAS.93.8.3492

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