Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
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A feline model of experimentally induced islet amyloidosisThe Rationale for Insulin Therapy in Alzheimer's DiseaseOn the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP PeptidesSex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type MiceHeparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complicationsActivation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation.Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts.Minireview: Estrogenic protection of beta-cell failure in metabolic diseases.The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer's disease.Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation.Endocrine amyloid--a subject of increasing interest for the next century.Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation.Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.TNF-α acutely upregulates amylin expression in murine pancreatic beta cells.Factors associated with beta-cell dysfunction in type 2 diabetes: the BETADECLINE study.Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity.Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.Type 2 diabetes and the aging pancreatic beta cell.Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity.Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.Glucose- and time-dependence of islet amyloid formation in vitro.Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55ProCerebral lipid deposition in aged apolipoprotein-E-deficient mice.Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cellsAccumulation of intrahepatic islet amyloid in a nonhuman primate transplant modelNuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.Translational control of glucose-induced islet amyloid polypeptide production in pancreatic isletsDetermination of Optimal Sample Size for Quantification of β-Cell Area, Amyloid Area and β-Cell Apoptosis in Isolated IsletsPancreatic function, type 2 diabetes, and metabolism in aging.Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced ToxicityFeline models of type 2 diabetes mellitus.Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptideHuman islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.Disturbed alpha-cell function in mice with beta-cell specific overexpression of human islet amyloid polypeptideIslet β cell mass in diabetes and how it relates to function, birth, and death.Is Glucagon-like peptide-1, an agent treating diabetes, a new hope for Alzheimer's disease?Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.
P2860
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P2860
Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Islet amyloid formation associ ...... man islet amyloid polypeptide.
@en
Islet amyloid formation associ ...... man islet amyloid polypeptide.
@nl
type
label
Islet amyloid formation associ ...... man islet amyloid polypeptide.
@en
Islet amyloid formation associ ...... man islet amyloid polypeptide.
@nl
prefLabel
Islet amyloid formation associ ...... man islet amyloid polypeptide.
@en
Islet amyloid formation associ ...... man islet amyloid polypeptide.
@nl
P2093
P2860
P356
P1476
Islet amyloid formation associ ...... uman islet amyloid polypeptide
@en
P2093
C B Verchere
D A D'Alessio
D G Baskin
R D Palmiter
S Bonner-Weir
P2860
P304
P356
10.1073/PNAS.93.8.3492
P407
P577
1996-04-01T00:00:00Z