Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.
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Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradationCXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenograftsActivation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation.Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cellsA de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasiaFocal adhesion kinase and endothelial cell apoptosis.Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response.Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.N-MYC regulates focal adhesion kinase expression in human neuroblastoma.Receptor-interacting protein shuttles between cell death and survival signaling pathwaysAn aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer.Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivoFocal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisInhibition of focal adhesion kinase decreases tumor growth in human neuroblastomaDownregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cellsPgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity.Receptor-interacting protein (RIP) kinase family.Nanotopographical modification: a regulator of cellular function through focal adhesions.The sodium channel β1 subunit mediates outgrowth of neurite-like processes on breast cancer cells and promotes tumour growth and metastasis.Anoikis mediators in oral squamous cell carcinoma.Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines.Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival.FAK regulates cardiomyocyte survival following ischemia/reperfusion.Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanolGenome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells.Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles.A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group.Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expressionA20 inhibits the motility of HCC cells induced by TNF-αSirtuin-3 (SIRT3) and the Hallmarks of Cancer.Focal adhesion kinase versus p53: apoptosis or survival?FERM control of FAK function: implications for cancer therapy.Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines.Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumorsFocal adhesion kinase and p53 signal transduction pathways in cancer.
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P2860
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2004
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Focal adhesion kinase suppress ...... receptor-interacting protein.
@en
Focal adhesion kinase suppress ...... receptor-interacting protein.
@nl
type
label
Focal adhesion kinase suppress ...... receptor-interacting protein.
@en
Focal adhesion kinase suppress ...... receptor-interacting protein.
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prefLabel
Focal adhesion kinase suppress ...... receptor-interacting protein.
@en
Focal adhesion kinase suppress ...... receptor-interacting protein.
@nl
P2093
P2860
P1476
Focal adhesion kinase suppress ...... receptor-interacting protein.
@en
P2093
Albert S Baldwin
Elena Kurenova
Rolf J Craven
Steven K Hanks
William G Cance
Xihui Yang
Zheng-Gang Liu
P2860
P304
P356
10.1128/MCB.24.10.4361-4371.2004
P407
P577
2004-05-01T00:00:00Z