Interactions between Hedgehog proteins and their binding partners come into view.
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Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammalsStructural insights into proteoglycan-shaped Hedgehog signalingA mutation in the mouse ttc26 gene leads to impaired hedgehog signalingSmoothened goes molecular: new pieces in the hedgehog signaling puzzleRequirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.Cilia in the CNS: the quiet organelle claims center stageOverlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptorsA new role for Hedgehogs in juxtacrine signaling.Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling.Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation.Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates.Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form.A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndromeSecreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and functionIncreased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.Cooperative Hedgehog-EGFR signaling46,XY Gonadal Dysgenesis due to a Homozygous Mutation in Desert Hedgehog (DHH) Identified by Exome SequencingTargeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical updateComputational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathwayHedgehog secretion and signal transduction in vertebrates.Regulation of Hedgehog signaling by ubiquitination.Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways.Castor is required for Hedgehog-dependent cell-fate specification and follicle stem cell maintenance in Drosophila oogenesis.Diet controls Drosophila follicle stem cell proliferation via Hedgehog sequestration and releaseSmoothened is a master regulator of adult liver repair.The role of ciliary trafficking in Hedgehog receptor signaling.The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy.Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH.Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferationDecisions on the fly in cellular sensory systemsSilencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancerTargeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis.Hedgehog signaling: networking to nurture a promalignant tumor microenvironment.Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies.The Hedgehog signal transduction network.
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P2860
Interactions between Hedgehog proteins and their binding partners come into view.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Interactions between Hedgehog proteins and their binding partners come into view.
@en
Interactions between Hedgehog proteins and their binding partners come into view.
@nl
type
label
Interactions between Hedgehog proteins and their binding partners come into view.
@en
Interactions between Hedgehog proteins and their binding partners come into view.
@nl
prefLabel
Interactions between Hedgehog proteins and their binding partners come into view.
@en
Interactions between Hedgehog proteins and their binding partners come into view.
@nl
P2093
P2860
P356
P1433
P1476
Interactions between Hedgehog proteins and their binding partners come into view.
@en
P2093
Christian Siebold
Daniel J Leahy
Philip A Beachy
Robert A Lazarus
Sarah G Hymowitz
P2860
P304
P356
10.1101/GAD.1951710
P577
2010-09-01T00:00:00Z