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The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolismA new computational method for the detection of horizontal gene transfer eventsA sensitive, support-vector-machine method for the detection of horizontal gene transfers in viral, archaeal and bacterial genomes.Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genesHiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking.Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes.N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration.lncRNA-screen: an interactive platform for computationally screening long non-coding RNAs in large genomics datasets.Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma.Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.Combinatorial modulation of signaling pathways reveals cell-type-specific requirements for highly efficient and synchronous iPSC reprogramming.Accurate phylogenetic classification of variable-length DNA fragments.Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-GenomicsFBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolismAutophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone productionCohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasmsThe milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis.Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.Pancreatic β cell identity requires continual repression of non-β cell programs.MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: connecting fibrosis, inflammation, and stemness for cancer prevention.The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox.Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.Bacteriophages as potential new mammalian pathogens.Complete Genome Sequence of Kluyvera intestini sp. nov., Isolated from the Stomach of a Patient with Gastric Cancer.Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.GenomicTools: a computational platform for developing high-throughput analytics in genomics.OMiR: Identification of associations between OMIM diseases and microRNAs.H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition.A conserved activation element in BMP signaling during Drosophila development.Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex.Staphylococcus aureus Responds to the Central Metabolite Pyruvate To Regulate Virulence.Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries.TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma.
P50
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P50
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hulumtues
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onderzoeker
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հետազոտող
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Aristotelis Tsirigos
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Aristotelis Tsirigos
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Aristotelis Tsirigos
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Aristotelis Tsirigos
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Aristotelis Tsirigos
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Aristotelis Tsirigos
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Aristotelis Tsirigos
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Aristotelis Tsirigos
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P106
P21
P31
P496
0000-0002-7512-8477