The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox.
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Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cellsCilia in autophagy and cancerAutophagy in stem cells.Molecular pathways: trafficking of metabolic resources in the tumor microenvironmentAdipose tissue and adipocytes support tumorigenesis and metastasisOncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discoveryAdvances in targeting signal transduction pathwaysInterplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapyCaveolin-1 and mitochondrial alterations in regenerating rat liverAddition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohortInteractions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells.Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling.The footprint of the ageing stroma in older patients with breast cancer.Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers.Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumorsAdipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradationCaveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblastsExpression of autophagy-related protein Beclin-1 in malignant canine mammary tumors.Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-GenomicsEvidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator.Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis.Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells.The complex interplay between autophagy and NF-κB signaling pathways in cancer cellsAutophagy in brain tumors: a new target for therapeutic intervention.Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo.Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolismUsing the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers.Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue.Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone productionCaveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drugTwo-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cellsMolecular chess? Hallmarks of anti-cancer drug resistance
P2860
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P2860
The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
The autophagic tumor stroma mo ...... tion to the autophagy paradox.
@en
The autophagic tumor stroma mo ...... tion to the autophagy paradox.
@nl
type
label
The autophagic tumor stroma mo ...... tion to the autophagy paradox.
@en
The autophagic tumor stroma mo ...... tion to the autophagy paradox.
@nl
prefLabel
The autophagic tumor stroma mo ...... tion to the autophagy paradox.
@en
The autophagic tumor stroma mo ...... tion to the autophagy paradox.
@nl
P2093
P2860
P50
P356
P1433
P1476
The autophagic tumor stroma mo ...... tion to the autophagy paradox.
@en
P2093
Agnieszka Witkiewicz
Barbara Chiavarina
Chengwang Wang
Gemma Migneco
Gloria Bonuccelli
Isabelle Mercier
Jaime Caro
Neal Flomenberg
Renee Balliet
Richard G Pestell
P2860
P304
P356
10.4161/CC.9.21.13817
P50
P577
2010-11-30T00:00:00Z