Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.

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Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection.Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes Evaluation of a novel PXR-knockout in HepaRG™ cells.

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Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.

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Methods for the quantitative e ...... using human in vitro systems.

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Methods for the quantitative e ...... using human in vitro systems.

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Methods for the quantitative e ...... using human in vitro systems.

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P1476

Methods for the quantitative e ...... using human in vitro systems.

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Hiroshi Suzuki

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Masanari Kozawa

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Masashi Honma

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats

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491-511

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scholarly article

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10.1517/17460441003762717

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English

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2010-05-01T00:00:00Z

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22823132

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Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.

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P2860

P2860

Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.

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P1476

P2093

P2860

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P2860

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P698