The Bcl-2 family: structures, interactions and targets for drug discovery.
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The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation.Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim.MCL-1, BCL-XL and MITF Are Diversely Employed in Adaptive Response of Melanoma Cells to Changes in Microenvironment.Suppression of pancreatic beta cell apoptosis by Danzhi Jiangtang capsule contributes to the attenuation of type 1 diabetes in ratsUpregulation of miR-195 enhances the radiosensitivity of breast cancer cells through the inhibition of BCL-2.Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain.Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability.Development of a lytic peptide derived from BH3-only proteinsBcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis.Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury.Pre-clinical characterization of PKC412, a multi-kinase inhibitor, against colorectal cancer cellsEmodin protects against oxidative stress and apoptosis in HK-2 renal tubular epithelial cells after hypoxia/reoxygenationProtein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells.Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling.Molecular mechanisms for tumor resistance to chemotherapy.RNA-seq comparative analysis of Peking ducks spleen gene expression 24 h post-infected with duck plague virulent or attenuated virus.Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis.Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis.Structural basis of apoptosis inhibition by the fowlpox virus protein FPV039.Comment on "Renal Protective Effect of Sirtuin 1".Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-induced hypertension.3-n-Butylphthalide reduces the oxidative damage of muscles in an experimental autoimmune myositis animal modelThe Bcl-2 Family in Host-Virus Interactions.Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.Nanoparticle Delivery of Artesunate Enhances the Anti-tumor Efficiency by Activating Mitochondria-Mediated Cell Apoptosis.Human Thyroid Cancer-1 (TC-1) is a vertebrate specific oncogenic protein that protects against copper and pro-apoptotic genes in yeast.Double quick, double click reversible peptide "stapling".Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis.Bcl-2 protects TK6 cells against hydroquinone-induced apoptosis through PARP-1 cytoplasm translocation and stabilizing mitochondrial membrane potential.The BCL-2 arbiters of apoptosis and their growing role as cancer targets.Overexpression of CCDC34 in colorectal cancer and its involvement in tumor growth, apoptosis and invasion.Combination of betulinic acid with diazen-1-ium-1,2-diolate nitric oxide moiety donating a novel anticancer candidate.Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells.The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth.Paeoniflorin induces G2/M cell cycle arrest and caspase-dependent apoptosis through the upregulation of Bcl-2 X-associated protein and downregulation of B-cell lymphoma 2 in human osteosarcoma cells.Apoptosis turns 21.Therapeutic targeting of leukemic stem cells in acute myeloid leukemia - the biological background for possible strategies.Effects and mechanism of amyloid β1-42 on mitochondria in astrocytes.Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.Regulatory role of calpain in neuronal death.
P2860
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P2860
The Bcl-2 family: structures, interactions and targets for drug discovery.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
The Bcl-2 family: structures, interactions and targets for drug discovery.
@en
type
label
The Bcl-2 family: structures, interactions and targets for drug discovery.
@en
prefLabel
The Bcl-2 family: structures, interactions and targets for drug discovery.
@en
P2860
P1433
P1476
The Bcl-2 family: structures, interactions and targets for drug discovery.
@en
P2093
Mark G Hinds
P2860
P2888
P304
P356
10.1007/S10495-014-1051-7
P577
2015-02-01T00:00:00Z