Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.
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Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stressCurcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive elementCommon features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiaeThe importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current stateThe Nrf2/HO-1 Axis in Cancer Cell Growth and ChemoresistanceRedox Modulating NRF2: A Potential Mediator of Cancer Stem Cell ResistanceThe Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseasesCytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytesNrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasiaOxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathwayNrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genesProtective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicityNuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung FibrosisNrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cellsThe Keap1-Nrf2 system in cancers: stress response and anabolic metabolismMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseMetabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type miceThe role of Nrf1 and Nrf2 in the regulation of copper-responsive transcriptionEvaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assayGlutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1Cloning and expression of a novel Mu class murine glutathione transferase isoenzymeNrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expressionDistinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stressLoss of GSTM1, a NRF2 target, is associated with accelerated progression of hypertensive kidney disease in the African American Study of Kidney Disease (AASK).Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.Glutathione S-transferase-micro1 regulates vascular smooth muscle cell proliferation, migration, and oxidative stress.A genomic screen for activators of the antioxidant response elementTranscriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGENrf2 signaling, a mechanism for cellular stress resistance in long-lived mice.Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout miceUtility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.Mammary gene expression profiles during an intramammary challenge reveal potential mechanisms linking negative energy balance with impaired immune responseKeap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.
P2860
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P2860
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Loss of the Nrf2 transcription ...... ivers of male and female mice.
@en
type
label
Loss of the Nrf2 transcription ...... ivers of male and female mice.
@en
prefLabel
Loss of the Nrf2 transcription ...... ivers of male and female mice.
@en
P2093
P2860
P50
P356
P1433
P1476
Loss of the Nrf2 transcription ...... livers of male and female mice
@en
P2093
Clifford R Elcombe
Gail K McWalter
Graeme J Moffat
Lesley I McLellan
Masayuki Yamamoto
Michael McMahon
Qing Jiang
Simon A Chanas
P2860
P304
P356
10.1042/BJ20020320
P407
P577
2002-07-01T00:00:00Z