Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.
about
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcriptionThe Nrf2-antioxidant response element signaling pathway and its activation by oxidative stressActivation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interactionFocal adhesions regulate Abeta signaling and cell death in Alzheimer's diseaseThe Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseasesConcerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damageHydrogen peroxide sensing, signaling and regulation of transcription factorsTrxR1 as a potent regulator of the Nrf2-Keap1 response systemNrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting functionNegative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulumKeap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondriaStress-activated cap'n'collar transcription factors in aging and human diseaseCACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disordersBasic principles and emerging concepts in the redox control of transcription factorsRegulation of signal transduction by reactive oxygen species in the cardiovascular systemAntioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistanceNuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defensesSelective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian CellsAltered transcription factor trafficking in oxidatively-stressed neuronal cells.Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress responseThe role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryoKeratins Are Going NuclearKeap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver.Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.Effects of interventions on oxidative stress and inflammation of cardiovascular diseasesThe ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.The Nrf2-ARE cytoprotective pathway in astrocytes.Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence.Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in miceExpression of Nrf2 in neurodegenerative diseasesMultiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2.Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease preventionPart of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer.Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism.Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation.Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease.
P2860
Q24310885-C16CFAD8-8F6E-4B76-9559-AAFCB8B92B79Q24648021-B90D7E25-3A19-4F3A-9CE6-A10F6893E0F1Q24656061-5CA97305-53BE-4294-B912-8AF0237D3740Q24681610-C830447F-7B6B-4C97-BBB9-8C1648731472Q26822972-40278F45-F85D-4D0E-883F-AE1B2BF1ED49Q26995211-7D419B33-E5B9-4A98-A851-904845FC9BD4Q27004438-DCDFB54D-1FF9-43EF-8CE5-387ADD82C4F6Q28080723-DE82A01F-5172-455D-9A62-48EF5A8825FAQ28239381-1BD85421-C985-4FFB-8269-62146BA27CDEQ28254462-FD64B85E-9E7F-42E5-9DE7-6719336BB417Q28382872-FC82CBAE-3B16-4593-923A-A82171AECF60Q28384526-1477C5CA-23CD-45CE-A7E4-30D869A3A6CAQ28384783-A7283BAE-92C0-47F3-B1AE-F0DD2D2F6DD6Q28384997-E33299AC-7331-4F2A-948B-C3FDCB9F6F88Q28386313-28541664-C7D4-4E2F-816F-CD9E7D946B9CQ28391506-BD2AB480-437D-498D-908D-72AD96C68D65Q28391569-F7296D5D-36D3-49E2-BCE1-1133C753E72DQ28392399-977C3F73-FBFD-4883-A951-97DDE98A4263Q28394814-29D8F3D7-4470-44C5-8E52-20EE91029EAFQ28554595-ACBDF183-2E15-4C7B-B2F4-042664988148Q30419484-9ADF4FC0-D26B-4322-B796-FF84A20A307EQ33576139-0306A74B-47BD-4418-9807-112F4549FDCAQ33763635-8AB5693A-1BF0-4A64-AE50-ECC97D4B70E6Q33906758-15E05E2F-5308-4D78-B374-07879A9F0732Q34028523-6966F23A-9366-4202-9B1C-7014587C9ED0Q34498927-3A38B1BE-7ECC-467C-802B-A031C0FBE62EQ34538729-699243F6-F1AE-40DE-91E7-2B264001D9F2Q34960760-01BF1670-DECA-44C1-A915-514E30D02F47Q34984506-D5CC0690-BCF7-441D-ADC1-9DE4BF6F64A1Q35832006-FE0098CE-FF33-4112-A982-0A342D49B127Q35851546-7EC99639-28DF-485B-8F3E-EFC75409DC82Q35914005-98DA204A-62DD-49B9-AC7D-161206C926D8Q36249355-AD496B72-A8B2-4FF2-85DC-0E77A30EA008Q36477584-E04D17E6-DB63-4DE1-8CA6-6EA15BED6ECBQ36512148-16A62C83-2651-421B-82B2-202825CB219DQ36539849-6B067FC2-C6E6-49D7-8888-5DB47BF8E31FQ36610404-BA237340-F058-47EE-82F6-76336B75F407Q36642707-8331F178-A71C-4129-AA12-3E49B9B160BEQ36719259-70383C51-6545-432F-AED6-138D0F8D53E4Q36846919-1C5A432F-7AD4-4465-A0A2-74627EE06EA5
P2860
Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Keap1 regulates the oxidation- ...... dent nuclear export mechanism.
@ast
Keap1 regulates the oxidation- ...... dent nuclear export mechanism.
@en
type
label
Keap1 regulates the oxidation- ...... dent nuclear export mechanism.
@ast
Keap1 regulates the oxidation- ...... dent nuclear export mechanism.
@en
prefLabel
Keap1 regulates the oxidation- ...... dent nuclear export mechanism.
@ast
Keap1 regulates the oxidation- ...... dent nuclear export mechanism.
@en
P2860
P1476
Keap1 regulates the oxidation- ...... dent nuclear export mechanism.
@en
P2093
Michaella Velichkova
Tama Hasson
P2860
P304
P356
10.1128/MCB.25.11.4501-4513.2005
P407
P577
2005-06-01T00:00:00Z