Mechanism of acceleration of antithrombin-proteinase reactions by low affinity heparin. Role of the antithrombin binding pentasaccharide in heparin rate enhancement.
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Recombinant human pigment epithelium-derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cellsInteraction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.Glycosaminoglycan-binding properties and kinetic characterization of human heparin cofactor II expressed in Escherichia coliHeparan sulfate 3-O-sulfation: a rare modification in search of a function.Sucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor IIHeparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor.Plasma free fatty acid levels influence Zn(2+) -dependent histidine-rich glycoprotein-heparin interactions via an allosteric switch on serum albumin.Investigation of the heparin-thrombin interaction by dynamic force spectroscopySulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases.Fluorescent reporters of thrombin, heparin cofactor II, and heparin binding in a ternary complex.The central role of thrombin in hemostasis.A comprehensive mathematical model for three-body binding equilibriaThe signature 3-O-sulfo group of the anticoagulant heparin sequence is critical for heparin binding to antithrombin but is not required for allosteric activation.Critical role of the linker region between helix D and strand 2A in heparin activation of antithrombin.Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.Mechanism of catalysis of inhibition of factor IXa by antithrombin in the presence of heparin or pentasaccharide.Characterization of the conformational alterations, reduced anticoagulant activity, and enhanced antiangiogenic activity of prelatent antithrombinMechanistic and therapeutic overview of glycosaminoglycans: the unsung heroes of biomolecular signaling.HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.The heparin-binding site of antithrombin is crucial for antiangiogenic activityAntiangiogenic forms of antithrombin specifically bind to the anticoagulant heparin sequence.Conformational changes in thrombin when complexed by serpins.Antithrombin-mediated anticoagulant activity of sulfated polysaccharides: different mechanisms for heparin and sulfated galactans.The heparin binding properties of heparin cofactor II suggest an antithrombin-like activation mechanism.Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activityN-glycans and the N terminus of protein C inhibitor affect the cofactor-enhanced rates of thrombin inhibition.Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa.Deconvolution of the fluorescence emission spectrum of human antithrombin and identification of the tryptophan residues that are responsive to heparin binding.
P2860
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P2860
Mechanism of acceleration of antithrombin-proteinase reactions by low affinity heparin. Role of the antithrombin binding pentasaccharide in heparin rate enhancement.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Mechanism of acceleration of a ...... e in heparin rate enhancement.
@en
type
label
Mechanism of acceleration of a ...... e in heparin rate enhancement.
@en
prefLabel
Mechanism of acceleration of a ...... e in heparin rate enhancement.
@en
P2093
P2860
P356
P1476
Mechanism of acceleration of a ...... e in heparin rate enhancement.
@en
P2093
P2860
P304
P356
10.1074/JBC.270.16.9043
P407
P577
1995-04-01T00:00:00Z