Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.
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The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regionsA Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding ProteinsCleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparinStructure of heparin-derived tetrasaccharide complexed to the plasma protein antithrombin derived from NOEs, J-couplings and chemical shifts.Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding site.Enzymatic synthesis of heparin related polysaccharides on sensor chips: rapid screening of heparin-protein interactions.Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence(s).Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.Sucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor IIDesigning nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa.Chemical Sulfation of Small Molecules - Advances and Challenges.Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.Allosteric activation of antithrombin critically depends upon hinge region extension.Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides.On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.Toward a robust computational screening strategy for identifying glycosaminoglycan sequences that display high specificity for target proteins.Heparin-protein interactions.Monitoring of heparin and its low-molecular-weight analogs by silicon field effect.Mechanisms of glycosaminoglycan activation of the serpins in hemostasis.Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cellsAllosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants.Investigating changes in the gas-phase conformation of Antithrombin III upon binding of Arixtra using traveling wave ion mobility spectrometry (TWIMS).Heparin sequencing brings structure to the function of complex oligosaccharides.Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.Saturation Mutagenesis of the Antithrombin Reactive Center Loop P14 Residue Supports a Three-step Mechanism of Heparin Allosteric Activation Involving Intermediate and Fully Activated StatesSerpins in T cell immunity.On designing non-saccharide, allosteric activators of antithrombin.Capillary electrophoretic study of small, highly sulfated, non-sugar molecules interacting with antithrombin.The signature 3-O-sulfo group of the anticoagulant heparin sequence is critical for heparin binding to antithrombin but is not required for allosteric activation.Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor Xa inhibition.Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors.Limitations of conventional anticoagulant therapy and the promises of non-heparin based conformational activators of antithrombin.New targets for glycosaminoglycans and glycosaminoglycans as novel targets.Antithrombin-binding octasaccharides and role of extensions of the active pentasaccharide sequence in the specificity and strength of interaction. Evidence for very high affinity induced by an unusual glucuronic acid residue.Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding.Antithrombin-binding oligosaccharides: structural diversities in a unique function?The effect of a reducing-end extension on pentasaccharide binding by antithrombin.Critical role of the linker region between helix D and strand 2A in heparin activation of antithrombin.Conformational selection of the AGA*IA(M) heparin pentasaccharide when bound to the fibroblast growth factor receptor.
P2860
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P2860
Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Mechanism of heparin activatio ...... ivated states of antithrombin.
@en
type
label
Mechanism of heparin activatio ...... ivated states of antithrombin.
@en
prefLabel
Mechanism of heparin activatio ...... ivated states of antithrombin.
@en
P2093
P2860
P356
P1476
Mechanism of heparin activatio ...... tivated states of antithrombin
@en
P2093
P2860
P304
P356
10.1074/JBC.273.13.7478
P407
P577
1998-03-01T00:00:00Z