The molecular-weight-dependence of the anti-coagulant activity of heparin.
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Synthesis of thrombin-inhibiting heparin mimetics without side effects.Direct evidence for a predominantly exolytic processive mechanism for depolymerization of heparin-like glycosaminoglycans by heparinase I.Mechanism of the anticoagulant action of heparin.Low-molecular-weight heparin and unfractionated heparin decrease Th-1, 2, and 17 expressionsEfficacy and safety of low-molecular-weight heparin (CY216) in preventing postoperative venous thrombo-embolism: a co-operative study.Low-molecular-weight heparin and prevention of postoperative deep vein thrombosis.Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence.Mapping the heparin-binding sites on type I collagen monomers and fibrils.Defining the domains of type I collagen involved in heparin- binding and endothelial tube formation.Effect of heparin and heparin fractions on platelet aggregationSulfonation of papain-treated chitosan and its mechanism for anticoagulant activity.Structure of the antithrombin-binding site in heparin.Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: development of a sensitive electrophoretic approach.Fractionation of heparin by chromatography on a tissue plasminogen activator-Sepharose columnChemoenzymatic synthesis of the next generation of ultralow MW heparin therapeutics.Biosynthesis of heparin and heparan sulfate.Mechanism of acceleration of antithrombin-proteinase reactions by low affinity heparin. Role of the antithrombin binding pentasaccharide in heparin rate enhancement.The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.The N-terminal segment of antithrombin acts as a steric gate for the binding of heparin.The effect of Ca2+, phospholipid and factor V on the anti-(factor Xa) activity of heparin and its high-affinity oligosaccharides.Mechanism of inhibition of mammalian DNA topoisomerase I by heparin.Effect of a pentosan polysulphate upon thrombin and factor Xa inactivation by antithrombin III.Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III.Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4Binding of platelet factor 4 to heparin oligosaccharides.The molecular size of the antithrombin-binding sequence in heparin.A historical perspective of the biophysics of the thrombin-heparin system: an example of nonspecific binding and the consequent parking problem in action.Pharmacology and special clinical applications of low-molecular-weight heparins.Insulin-like growth factor (IGF) binding protein-3 regulation of IGF-I is altered in an acidic extracellular environment.Glycosaminoglycans and the regulation of blood coagulation.Heparin interferes with translocation of Yop proteins into HeLa cells and binds to LcrG, a regulatory component of the Yersinia Yop apparatus.Platelet antiheparin proteins and antithrombin III interact with different binding sites on heparin molecule.Sequence analysis of heparan sulphate indicates defined location of N-sulphated glucosamine and iduronate 2-sulphate residues proximal to the protein-linkage region.The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa, factor XIa, factor XIIa and kallikrein by antithrombin.Heterogeneous distribution of antithrombin-binding sites in rat brain heparan sulphate proteoglycans.Endothelial binding sites for heparin. Specificity and role in heparin neutralization.The antiheparin effect of a heparinoid, pentosan polysulphate. Investigation of a mechanism.Determination of the pKa of glucuronic acid and the carboxy groups of heparin by 13C-nuclear-magnetic-resonance spectroscopyProperties of antithrombin-thrombin complex formed in the presence and in the absence of heparinDistribution of iduronate 2-sulphate residues in heparan sulphate. Evidence for an ordered polymeric structure
P2860
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P2860
The molecular-weight-dependence of the anti-coagulant activity of heparin.
description
1978 nî lūn-bûn
@nan
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
1978年论文
@zh
1978年论文
@zh-cn
name
The molecular-weight-dependence of the anti-coagulant activity of heparin.
@en
type
label
The molecular-weight-dependence of the anti-coagulant activity of heparin.
@en
prefLabel
The molecular-weight-dependence of the anti-coagulant activity of heparin.
@en
P2093
P2860
P356
P1433
P1476
The molecular-weight-dependence of the anti-coagulant activity of heparin.
@en
P2093
P2860
P304
P356
10.1042/BJ1750691
P407
P50
P577
1978-11-01T00:00:00Z