The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation.
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Active site opening and closure control translocation of multisubunit RNA polymeraseStable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnetPyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B PolymeraseMechanism of Hepatitis C Virus RNA Polymerase Inhibition with DihydroxypyrimidinesPhosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA PolymeraseIdentification of a new motif in family B DNA polymerases by mutational analyses of the bacteriophage t4 DNA polymerase.Interactions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-templateThe Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Engineering processive DNA polymerases with maximum benefit at minimum costReverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.RNA transcript 3'-proximal sequence affects translocation bias of RNA polymerase.Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovirFormation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybridsThymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme.Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition.K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies.Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonatesHIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling.Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.The RNA triphosphatase domain of L protein of Rinderpest virus exhibits pyrophosphatase and tripolyphosphatase activities.Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase.HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.T7 RNA polymerase studied by force measurements varying cofactor concentration.Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.The mechano-chemistry of a monomeric reverse transcriptase.Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition.3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.
P2860
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P2860
The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation.
description
2006 nî lūn-bûn
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
@zh-hk
2006年論文
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2006年論文
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2006年论文
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2006年论文
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name
The pyrophosphate analogue fos ...... l of polymerase translocation.
@en
type
label
The pyrophosphate analogue fos ...... l of polymerase translocation.
@en
prefLabel
The pyrophosphate analogue fos ...... l of polymerase translocation.
@en
P2093
P2860
P356
P1476
The pyrophosphate analogue fos ...... l of polymerase translocation.
@en
P2093
Bruno Marchand
Egor P Tchesnokov
Matthias Götte
P2860
P304
P356
10.1074/JBC.M607710200
P407
P577
2006-11-30T00:00:00Z