about
Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc ComplexLapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffoldsStructural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokineDiscovery of novel membrane binding structures and functionsMethods of protein structure comparison.Compound activity prediction using models of binding pockets or ligand properties in 3D.Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).Optimization of high throughput virtual screening by combining shape-matching and docking methods.Improved docking, screening and selectivity prediction for small molecule nuclear receptor modulators using conformational ensembles.The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transferViral infection controlled by a calcium-dependent lipid-binding module in ALIX.Structure based prediction of subtype-selectivity for adenosine receptor antagonistsStructural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.Crystal Structure of the Human Cannabinoid Receptor CB1.Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies.Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines.Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes.Towards a structural understanding of allosteric drugs at the human calcium-sensing receptorSynthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery.AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone.Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.Structural basis of ligand interaction with atypical chemokine receptor 3.Identification of novel serotonin transporter compounds by virtual screening.In silico analysis of the conservation of human toxicity and endocrine disruption targets in aquatic species.PeptiSite: a structural database of peptide binding sites in 4D.Identifying ligands at orphan GPCRs: current status using structure-based approaches.Chemokines and their receptors: insights from molecular modeling and crystallography.A general method for site specific fluorescent labeling of recombinant chemokines.Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.Spatial chemical distance based on atomic property fields.Novel cGMP efflux inhibitors identified by virtual ligand screening (VLS) and confirmed by experimental studies.
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description
hulumtuese
@sq
researcher
@en
ricercatrice
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wetenschapper
@nl
հետազոտող
@hy
name
Irina Kufareva
@ast
Irina Kufareva
@en
Irina Kufareva
@es
Irina Kufareva
@nl
Irina Kufareva
@sl
type
label
Irina Kufareva
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Irina Kufareva
@en
Irina Kufareva
@es
Irina Kufareva
@nl
Irina Kufareva
@sl
prefLabel
Irina Kufareva
@ast
Irina Kufareva
@en
Irina Kufareva
@es
Irina Kufareva
@nl
Irina Kufareva
@sl
P106
P21
P214
90147423121544881620
P2456
P31
P496
0000-0001-9083-7039
P6023
P735
P7859
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