Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage.
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(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerasesBioflavonoids as poisons of human topoisomerase II alpha and II betaDietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancementTargeting DNA topoisomerase II in cancer chemotherapySUMO-2/3 regulates topoisomerase II in mitosisDifferential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I.Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.(-)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIα inhibition and reactive oxygen speciesNatural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIαIncreased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.Isobenzofuranone derivatives exhibit antileishmanial effect by inhibiting type II DNA topoisomerase and inducing host response.Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanismBacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridgeDNA topoisomerase II as a target for cancer chemotherapy.Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageDNA topoisomerases participate in fragility of the oncogene RET.Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.Etoposide quinone is a redox-dependent topoisomerase II poisonSwitch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors.Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIαEffects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases.Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors.XK469, a selective topoisomerase IIbeta poison.Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86.Oxidative metabolites of curcumin poison human type II topoisomerases.Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes.Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα.The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cellsEpimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.The perinucleolar compartment is directly associated with DNA.
P2860
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P2860
Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Merbarone inhibits the catalyt ...... lpha by blocking DNA cleavage.
@en
type
label
Merbarone inhibits the catalyt ...... lpha by blocking DNA cleavage.
@en
prefLabel
Merbarone inhibits the catalyt ...... lpha by blocking DNA cleavage.
@en
P2860
P356
P1476
Merbarone inhibits the catalyt ...... lpha by blocking DNA cleavage.
@en
P2093
Fortune JM
Osheroff N
P2860
P304
17643-17650
P356
10.1074/JBC.273.28.17643
P407
P577
1998-07-01T00:00:00Z