A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. - Wikidata - wikimedia - TriplyDB

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

http://www.wikidata.org/entity/Q38336587

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Plant and animal pathogen recognition receptors signal through non-RD kinases Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses Low intensity pulsed ultrasound (LIPUS) influences the multilineage differentiation of mesenchymal stem and progenitor cell lines through ROCK-Cot/Tpl2-MEK-ERK signaling pathway Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice.TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling.Tumor progression locus 2 (Tpl2) kinase promotes chemokine receptor expression and macrophage migration during acute inflammation.Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.Anoikis effector Bit1 negatively regulates Erk activity.Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.Coordinating TLR-activated signaling pathways in cells of the immune system.Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma.TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-induced production of tumor necrosis factor-{alpha} and interleukin-12 in macrophages TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells.IκB kinase regulation of the TPL-2/ERK MAPK pathway.Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity.A multitude of kinases--which are the best targets in treating rheumatoid arthritis?Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation.Serine/threonine kinase, Cot/Tpl2, regulates renal cell apoptosis in ischaemia/reperfusion injury.Immunomodulatory properties of subcellular fractions of a G+ bacterium, Bacillus firmus.Iκb-ζ plays an important role in the ERK-dependent dysregulation of malaria parasite GPI-induced IL-12 expression.Bleomycin-induced lung injury in mice investigated by MRI: model assessment for target analysis.Involvement of Cot/Tp12 in bone loss during periodontitis.Benzo[a]pyrene-7,8-diol-9,10-epoxide inhibits gap junction intercellular communication via phosphorylation of tumor progression locus 2 in WB-F344 rat liver epithelial cells.Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: a comparison with leflunomide.Pharmacophore generation and atom-based 3D-QSAR of novel quinoline-3-carbonitrile derivatives as Tpl2 kinase inhibitors.Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling.TPL2 is a key regulator of intestinal inflammation in C. difficile infection.

P2860

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P2860

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

http://www.wikidata.org/entity/Q38336587

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

A serine/threonine kinase, Cot ...... n and Th cell differentiation.

@en

type

label

A serine/threonine kinase, Cot ...... n and Th cell differentiation.

@en

prefLabel

A serine/threonine kinase, Cot ...... n and Th cell differentiation.

@en

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Journal of Clinical Investigation

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A serine/threonine kinase, Cot ...... on and Th cell differentiation

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P2093

Akio Masuda

http://www.w3.org/2001/XMLSchema#string

Hiroyoshi Ishizaki

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Jun Miyoshi

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Kazuo Sugane

http://www.w3.org/2001/XMLSchema#string

Kenji Sugimoto

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Masaya Takamoto

http://www.w3.org/2001/XMLSchema#string

Mutsuhiro Ohata

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Seiichi Matsuo

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Tetsuya Matsuguchi

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Yasuhiro Shimada

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P2860

Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages

Structure and transforming potential of the human cot oncogene encoding a putative protein kinase

NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase

The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

Interleukin-10-deficient mice develop chronic enterocolitis

P304

857-866

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scholarly article

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10.1172/JCI20014

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10.1172/JCI200420014

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6

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114

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8343032

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15372110

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516257

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