Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. - Wikidata - wikimedia - TriplyDB

Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer.

Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer.

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Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2 Sulindac enhances the killing of cancer cells exposed to oxidative stress Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis.Current concepts in colorectal cancer prevention Meat consumption, nonsteroidal anti-inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers Study.Molecular alterations associated with sulindac-resistant colon tumors in ApcMin/+ mice Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients.Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect Indomethacin suppresses growth of colon cancer via inhibition of angiogenesis in vivo.Polyamines: total daily intake in adolescents compared to the intake estimated from the Swedish Nutrition Recommendations Objectified (SNO)DFMO: targeted risk reduction therapy for colorectal neoplasia.Variants downstream of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention.Association between the ornithine decarboxylase G316A polymorphism and breast cancer survival.Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography.Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine.Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?Emerging concepts in targeting the polyamine metabolic pathway in epithelial cancer chemoprevention and chemotherapy.β-Catenin and peroxisome proliferator-activated receptor-δ coordinate dynamic chromatin loops for the transcription of vascular endothelial growth factor A gene in colon cancer cells.Meat consumption, ornithine decarboxylase gene polymorphism, and outcomes after colorectal cancer diagnosis.Targeting polyamines and inflammation for cancer prevention New use for an old drug: COX-independent anti-inflammatory effects of sulindac in models of cystic fibrosis.A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia.Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator.Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation.A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model.Polyamine catabolism and disease.Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.Cancer chemoprevention locks onto a new polyamine metabolic target.The proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cells.COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines.Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity.Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models.Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc.

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P2860

Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer.

http://www.wikidata.org/entity/Q38350088

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2003年學術文章

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Cyclooxygenase-independent ind ...... by polyamines in colon cancer.

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Cyclooxygenase-independent ind ...... by polyamines in colon cancer.

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Cyclooxygenase-independent ind ...... by polyamines in colon cancer.

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Journal of Biological Chemistry

P1476

Cyclooxygenase-independent ind ...... by polyamines in colon cancer.

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Eugene W Gerner

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Natalia A Ignatenko

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Naveen Babbar

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Robert A Casero

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P2860

Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene

Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene

The ornithine decarboxylase gene is essential for cell survival during early murine development

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Measurement of protein using bicinchoninic acid

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene

The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

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10.1074/JBC.M307265200

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14506281

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apoptotic process