ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.
about
Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeastPhosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localizationMaking sense of eukaryotic DNA replication origins.Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycleAssembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinaseDNA synthesis at individual replication forks requires the essential initiation factor Cdc45pATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensingIdentification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2Spatial distribution and specification of mammalian replication origins during G1 phase.Mechanisms for initiating cellular DNA replicationThe B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formationMcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.Architecture of the yeast origin recognition complex bound to origins of DNA replication.Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.Nucleosome positioning at the replication forkThe Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cellsCdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.Cdc45 limits replicon usage from a low density of preRCs in mammalian cellsTemporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesisBi-directional replication and random termination.DNA repair in a yeast origin of replication: contributions of photolyase and nucleotide excision repair.Activation of silent replication origins at autonomously replicating sequence elements near the HML locus in budding yeast.DNA replication forks pause at silent origins near the HML locus in budding yeastIn search of the holy replicatorMammalian nuclei become licensed for DNA replication during late telophaseSite-specific ORC binding, pre-replication complex assembly and DNA synthesis at Schizosaccharomyces pombe replication origins.Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA bindingFission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity.Roles for internal and flanking sequences in regulating the activity of mating-type-silencer-associated replication origins in Saccharomyces cerevisiae.The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin.Telomeric chromatin modulates replication timing near chromosome ends.DNA replication origin interference increases the spacing between initiation events in human cells.Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro.A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication.Activation of dormant origins of DNA replication in budding yeastThe hunt for origins of DNA replication in multicellular eukaryotes
P2860
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P2860
ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
ORC- and Cdc6-dependent comple ...... s in Saccharomyces cerevisiae.
@en
type
label
ORC- and Cdc6-dependent comple ...... s in Saccharomyces cerevisiae.
@en
prefLabel
ORC- and Cdc6-dependent comple ...... s in Saccharomyces cerevisiae.
@en
P2860
P1433
P1476
ORC- and Cdc6-dependent comple ...... s in Saccharomyces cerevisiae.
@en
P2093
Santocanale C
P2860
P304
P407
P577
1996-12-01T00:00:00Z