Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development. - Wikidata - wikimedia - TriplyDB

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

http://www.wikidata.org/entity/Q38350712

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Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2 Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells.Forced expression of cyclin-dependent kinase 6 confers resistance of pro-B acute lymphocytic leukemia to Gleevec treatment Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression Epigenetic regulation of antigen receptor gene rearrangement E proteins and the regulation of early lymphocyte development Requirement for cyclin D3 in germinal center formation and function.During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool Transition pattern and mechanism of B-lymphocyte precursors in regenerated mouse bone marrow after subtotal body irradiation Cyclin D3 is selectively required for proliferative expansion of germinal center B cells.Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes.DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3 Histone reader BRWD1 targets and restricts recombination to the Igk locus.Integrated signaling in developing lymphocytes: the role of DNA damage responses.RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells Lymphocyte development: integration of DNA damage response signaling.Balancing Proliferation with Igκ Recombination during B-lymphopoiesis Epigenetic regulation of V(D)J recombination.Ikaros in immune receptor signaling, lymphocyte differentiation, and function.The role of STAT5 in lymphocyte development and transformation Kras Is Critical for B Cell Lymphopoiesis.Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia.MAP Kinase Cascades in Antigen Receptor Signaling and Physiology.The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells.Signaling proteins and transcription factors in normal and malignant early B cell development.Y-box-binding protein 1 contributes to IL-7-mediated survival signaling in B-cell precursor acute lymphoblastic leukemia.A developmentally controlled competitive STAT5-PU.1 DNA binding mechanism regulates activity of the Ig κ E3' enhancer.The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development Ikaros, Helios, and Aiolos protein levels increase in human thymocytes after β selection.A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

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Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

http://www.wikidata.org/entity/Q38350712

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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Ras orchestrates exit from the ...... ring early B cell development.

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Nature Immunology

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Ras orchestrates exit from the ...... ring early B cell development.

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Barbara L Kee

http://www.w3.org/2001/XMLSchema#string

Harinder Singh

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Katia Georgopoulos

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Kyoko Ochiai

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Malay Mandal

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Marcus R Clark

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P2860

STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas

E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

The role of the Ikaros gene in lymphocyte development and homeostasis

Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor

Aiolos regulates B cell activation and maturation to effector state

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins

Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo

B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade.

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1110-1117

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10.1038/NI.1785

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10

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10

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26793929

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19734904

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3057509

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