Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress.
about
The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brainVacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosisNuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression.The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegenerationInduction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epitheliumMolecular dissection of reactive astrogliosis and glial scar formationThe Nrf2-antioxidant response element signaling pathway and its activation by oxidative stressCellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegenerationThe Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseasesIdebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signalingPathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2Oxidized cholesterol as the driving force behind the development of Alzheimer's diseaseThe conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegansImaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivoInterleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-dependent upregulation of glutathione synthesis.Astrocytes: biology and pathologyAdaptive regulation of the brain's antioxidant defences by neurons and astrocytesSerotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's DiseaseProtection by Neuroglobin Expression in Brain PathologiesFetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated proteinNrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2Dual TNFα-induced effects on NRF2 mediated antioxidant defence in astrocyte-rich cultures: role of protein kinase activationResveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in miceCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersStress-activated cap'n'collar transcription factors in aging and human disease4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cellsNeuronal activity regulates astrocytic Nrf2 signalingNeuroprotective effects of urate are mediated by augmenting astrocytic glutathione synthesis and releaseHIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorderNeuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotectionSOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI)The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitisDiscovery of potent, novel Nrf2 inducers via quantum modeling, virtual screening, and in vitro experimental validation.Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease.Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.
P2860
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P2860
Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Coordinate regulation of gluta ...... neurons from oxidative stress.
@en
type
label
Coordinate regulation of gluta ...... neurons from oxidative stress.
@en
prefLabel
Coordinate regulation of gluta ...... neurons from oxidative stress.
@en
P2093
P1476
Coordinate regulation of gluta ...... neurons from oxidative stress
@en
P2093
Andrew D Kraft
Andy Y Shih
Delinda A Johnson
Gloria Wong
Jeffrey A Johnson
Timothy H Murphy
P304
P356
10.1523/JNEUROSCI.23-08-03394.2003
P407
P577
2003-04-01T00:00:00Z