RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy.
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Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity.The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes.The bounty of RAGs: recombination signal complexes and reaction outcomes.Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctionsA non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2Molecular mechanism underlying RAG1/RAG2 synaptic complex formation.A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity.Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination.Mechanistic basis for RAG discrimination between recombination sites and the off-target sites of human lymphomas.An interdomain boundary in RAG1 facilitates cooperative binding to RAG2 in formation of the V(D)J recombinase complex.A high-throughput assay for Tn5 Tnp-induced DNA cleavage.
P2860
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P2860
RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
RAG1-DNA binding in V(D)J reco ...... orescence and CD spectroscopy.
@en
type
label
RAG1-DNA binding in V(D)J reco ...... orescence and CD spectroscopy.
@en
prefLabel
RAG1-DNA binding in V(D)J reco ...... orescence and CD spectroscopy.
@en
P2093
P2860
P356
P1476
RAG1-DNA binding in V(D)J reco ...... orescence and CD spectroscopy.
@en
P2093
David G Schatz
Frank V Bright
Gary A Baker
Leon M Ptaszek
Mihai Ciubotaru
Sheila N Baker
P2860
P304
P356
10.1074/JBC.M209758200
P407
P577
2002-12-17T00:00:00Z