Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. - Wikidata - wikimedia - TriplyDB

Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.

Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.

http://www.wikidata.org/entity/Q38360088

about

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin Erythroid phenotypes associated with KLF1 mutations The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis Mammalian Krüppel-like factors in health and diseases Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.Global transcriptome analyses of human and murine terminal erythroid differentiation.EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation Krüppel-like factors compete for promoters and enhancers to fine-tune transcription.HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.Erythropoiesis: development and differentiation.Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development The multifunctional role of EKLF/KLF1 during erythropoiesis.Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts.Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination.Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis.Novel methods for studying normal and disordered erythropoiesis.Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.Orchestration of late events in erythropoiesis by KLF1/EKLF.E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts Global analysis of induced transcription factors and cofactors identifies Tfdp2 as an essential coregulator during terminal erythropoiesis.Haemopedia: An Expression Atlas of Murine Hematopoietic Cells.EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation.

P2860

Q24293797-7092EFEE-4EBD-49FD-83F7-23C66DC226C0 Q24604912-4F109A7E-AFCF-4A5B-82E0-358073E55313 Q24606622-97C06A63-8B93-40A6-AD03-D543532B363F Q24606774-02E9A2D2-952A-4F78-8B8E-5EEA7D150AA0 Q24612560-1137F7D1-8B94-4231-AEEB-C1602776E227 Q24632948-4FF0F6F3-2BC6-4837-8A79-0324EE3BB59A Q26768269-A7F7E785-0153-44D9-BF20-807BA804F9D9 Q28600992-F8DF1CDE-0C31-41A8-9DD5-FC04C65EEFFD Q33569847-A9350B14-BE61-4883-A8AE-66AC8928BE46 Q33666771-34F326BD-E206-4E7E-BAB1-3686DE93D961 Q33697238-D40A70BE-534F-4358-BB97-72F7BB355CEA Q33877028-E7078AAD-97AC-4643-AA84-87843E2E95DD Q33879091-644C87ED-4CE6-4191-A8B4-9B74AAF6BF16 Q34067252-68D321F7-04EA-4168-B51B-907C072DB787 Q34272512-ADE1A6BF-F38B-4E68-8317-7F9C4DD00A14 Q34347327-98627A88-6163-477C-A613-222743172942 Q34463668-3756E04A-E289-4D0A-A729-0C330CD4B3BA Q34464896-18801BAC-86DD-447B-9599-D7BC7D78DA45 Q34649958-30AD3E55-9D13-4C34-920A-0C40B50E865B Q35525497-7E277C7D-FCB8-4332-85E2-AAC7502A0A5A Q35759986-7C4DA88C-9D7F-4B15-8E48-543F8C19D428 Q35797596-0A21EF81-54AB-4510-AA4A-8F73AA68FBF4 Q35913083-CC8AC898-4E40-4DE7-AD92-3D58FCFF0F4B Q35939797-3BA04C6E-68FD-48DD-9096-7CF9A7A70998 Q36352558-BB5C5DCB-7054-45F2-B7BF-3A5CBA78EB21 Q36424904-FCD9236E-1374-48A8-B870-F78FC0043B32 Q36446199-EE25BBB7-9432-4AAE-864F-3DB66F830BE9 Q36513024-F0B1F55A-B264-489C-A173-535CA45454C4 Q36584835-E38DED9E-6701-485F-B562-F45D0D0119EB Q37344087-0A99F137-F7FC-4F65-B575-631783DD4585 Q38054642-590D0FC7-D6BB-4206-86D5-095104845D2F Q38210855-3EC9E503-43CB-4444-9FF5-26302025E615 Q38630640-705878B3-97D3-4839-B34B-F58FC9781B3D Q38640493-E86EC049-AC34-44CA-85AA-AFAF37AF6BA6 Q38988198-1C7291A0-465E-4237-A29D-FB4310AF0577 Q39117886-5B65FE3C-2362-4FEA-AFFA-CDF7073AF94A Q39235418-023CEDB9-CBC5-4C1E-937E-C790110DF173 Q39235961-97E21448-B0BD-4C44-B189-1B10C430DC6A Q39515020-1D25C4C9-5393-4837-9705-0224B1BCB1A4 Q41168774-FE2F9177-FD1C-4608-B3A2-3724999FA534

P2860

Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.

http://www.wikidata.org/entity/Q38360088

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Failure of terminal erythroid ...... nd reduced expression of E2F2.

@en

type

label

Failure of terminal erythroid ...... nd reduced expression of E2F2.

@en

prefLabel

Failure of terminal erythroid ...... nd reduced expression of E2F2.

@en

P1433

Q38360088-82B10A40-5F7B-470A-8B0B-7B7C886CF8EA

P1476

Q38360088-34613397-AC64-482E-AE7F-BC0DFB01B0FA

P2093

Q38360088-35E61E0B-728F-4081-BA40-E124E3482B66

Q38360088-7C67E483-B4C9-4A60-B135-87568D075936

Q38360088-B5764070-98F4-4C22-A1B6-904B422BD42F

Q38360088-B732BC2D-C002-4096-8627-C369514398C3

Q38360088-C1A9DB4E-16E3-42DB-AD95-7CB2963C10AF

Q38360088-C8DCAEC0-EC0C-47D6-ADC8-E05ACC31FA5A

Q38360088-D0D52494-1D8A-47AA-B469-28A6CA3043F4

Q38360088-E989DD25-EA54-4F81-B51F-3459812E1BAC

P2860

Q38360088-0084B069-8FE1-4A64-B13D-A8A06FD0F186

Q38360088-184D590A-3BB2-48C7-91DB-9165940D5CA1

Q38360088-1D9E8E8E-4C86-4E1C-BDFF-D78B75F93929

Q38360088-25AD8181-08B3-4F55-9B8B-08439C92F552

Q38360088-2AF2082F-345D-4BD2-812E-CE5B4D238D7B

Q38360088-2C5CB3FF-5F4A-430D-84CC-12F09E2813AE

Q38360088-38A22DD5-E794-4A9E-8C3E-FF955CCB541A

Q38360088-4C4A2941-4D1D-403F-B2D9-6849C5D8D678

Q38360088-4D5C6821-1115-4D4F-AE8B-CA284D9B3608

Q38360088-4DA0A3A9-5639-48B9-BDC9-1C601EDB6081

P304

Q38360088-8DBB2116-D52E-4FAD-A741-9473D050D9B6

P31

Q38360088-E0E1216F-B0AB-492A-88D8-925846B4E123

P356

Q38360088-B8088A99-1F84-4667-9D9F-D9B53CC95B65

P407

Q38360088-9EA551AA-6F38-4EF3-8615-A73A2378054E

P433

Q38360088-DE1D68B5-F478-4822-BD0B-391E996A9D93

P478

Q38360088-A70FFC29-B233-4888-8ABF-7E2EB2766AEA

P577

Q38360088-DFDBC38A-D054-4B78-9255-E5210B41733A

P698

Q38360088-6F80C4A7-D21A-48AA-A2EC-779021B60065

P932

Q38360088-83AD7CB1-01FE-4C51-8F69-0B444B25C922

P356

P1433

Molecular and Cellular Biology

P1476

Failure of terminal erythroid ...... nd reduced expression of E2F2.

@en

P2093

Andre M Pilon

http://www.w3.org/2001/XMLSchema#string

David M Bodine

http://www.w3.org/2001/XMLSchema#string

Holly K Dressman

http://www.w3.org/2001/XMLSchema#string

Jose I Sangerman

http://www.w3.org/2001/XMLSchema#string

Murat O Arcasoy

http://www.w3.org/2001/XMLSchema#string

Patrick G Gallagher

http://www.w3.org/2001/XMLSchema#string

Serena E Vayda

http://www.w3.org/2001/XMLSchema#string

Yelena D Maksimova

http://www.w3.org/2001/XMLSchema#string

P2860

A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro

Functional selectivity of recombinant mammalian SWI/SNF subunits

Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region

Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter

A global role for EKLF in definitive and primitive erythropoiesis

Sp1- and Krüppel-like transcription factors

Transcriptional regulation of erythropoiesis: an affair involving multiple partners

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

The active spatial organization of the beta-globin locus requires the transcription factor EKLF

P304

7394-7401

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.01087-08

http://www.w3.org/2001/XMLSchema#string

P407

P433

24

http://www.w3.org/2001/XMLSchema#string

P478

28

http://www.w3.org/2001/XMLSchema#string

P577

2008-10-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18852285

http://www.w3.org/2001/XMLSchema#string

P932

2593440

http://www.w3.org/2001/XMLSchema#string