Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine.
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The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent mannerThe Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical ApplicationsNoscapine induced apoptosis via downregulation of survivin in human neuroblastoma cells having wild type or null p53Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agentsMyosin-10 and actin filaments are essential for mitotic spindle functionPaclitaxel induces apoptosis in human gastric carcinoma cells.Microtubules and their role in cellular stress in cancerNoscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathwayAntitumor activity of Noscapine in combination with Doxorubicin in triple negative breast cancer.Enhanced anticancer activity of gemcitabine in combination with noscapine via antiangiogenic and apoptotic pathway against non-small cell lung cancer.A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer.Decreased therapeutic effects of noscapine combined with imatinib mesylate on human glioblastoma in vitro and the effect of midkine.Drugs that target dynamic microtubules: a new molecular perspectiveSecond generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluationCYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism.Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model.Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.Noscapine chemosensitization enhances docetaxel anticancer activity and nanocarrier uptake in triple negative breast cancerCyclophosphamide alters the gene expression profile in patients treated with high doses prior to stem cell transplantation.Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A.Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth.Noscapine Increases the Sensitivity of Drug-Resistant Ovarian Cancer Cell Line SKOV3/DDP to Cisplatin by Regulating Cell Cycle and Activating Apoptotic Pathways.Rational design of biaryl pharmacophore inserted noscapine derivatives as potent tubulin binding anticancer agents.Biology-oriented synthesis of a tetrahydroisoquinoline-based compound collection targeting microtubule polymerization.In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-terminal kinase pathway.Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.Release of Mps1 from kinetochores is crucial for timely anaphase onset.p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells.Molecular modelling and competition binding study of Br-noscapine and colchicine provide insight into noscapinoid-tubulin binding siteDetermination of factors controlling the particle size and entrapment efficiency of noscapine in PEG/PLA nanoparticles using artificial neural networks.Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer.Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro.Cell cycle arrest and apoptogenic properties of opium alkaloids noscapine and papaverine on breast cancer stem cells.Synergistic Anticancer Effect of Paclitaxel and Noscapine on Human Prostate Cancer Cell Lines.
P2860
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P2860
Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Paclitaxel-resistant human ova ...... osis in response to noscapine.
@en
type
label
Paclitaxel-resistant human ova ...... osis in response to noscapine.
@en
prefLabel
Paclitaxel-resistant human ova ...... osis in response to noscapine.
@en
P2093
P2860
P356
P1476
Paclitaxel-resistant human ova ...... osis in response to noscapine.
@en
P2093
Dulal Panda
Harish C Joshi
Kamlesh Gupta
Keqiang Ye
Paraskevi Giannakakou
P2860
P304
39777-39785
P356
10.1074/JBC.M203927200
P407
P577
2002-08-14T00:00:00Z