Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.
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Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instabilityIsolation of a small molecule inhibitor of DNA base excision repair.Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATPHuman AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis riskOverview of base excision repair biochemistryEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleInsight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleasesAPE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survivalp53 coordinates base excision repair to prevent genomic instabilityTranscriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.Requirement for abasic endonuclease gene homologues in Arabidopsis seed development.Immunohistochemical analysis of oxidative stress and DNA repair proteins in normal mammary and breast cancer tissues.The many functions of APE1/Ref-1: not only a DNA repair enzymeIdentification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor.Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.Prognostic value of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in breast cancer.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Single cell trapping and DNA damage analysis using microwell arrays.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functionsInduction of apurinic endonuclease 1 overexpression by endoplasmic reticulum stress in hepatoma cells.Apurinic/apyrimidinic endonuclease/redox effector factor-1(APE/Ref-1): a unique target for the prevention and treatment of human melanoma.Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathySmall molecule inhibitors of DNA repair nuclease activities of APE1.Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1.Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model.Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancerKilling effect of Ad5/F35-APE1 siRNA recombinant adenovirus in combination with hematoporphrphyrin derivative-mediated photodynamic therapy on human nonsmall cell lung cancerFunctional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1.Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expressionApurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsIncreased human AP endonuclease 1 level confers protection against the paternal age effect in mice.Endothelial cell tumor growth is Ape/ref-1 dependentElevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease.
P2860
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P2860
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Human apurinic endonuclease 1 ...... NA APE1 expression inhibition.
@en
type
label
Human apurinic endonuclease 1 ...... NA APE1 expression inhibition.
@en
prefLabel
Human apurinic endonuclease 1 ...... NA APE1 expression inhibition.
@en
P2093
P1476
Human apurinic endonuclease 1 ...... NA APE1 expression inhibition.
@en
P2093
Mark R Kelley
Meihua Luo
P304
P577
2004-06-01T00:00:00Z