Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles.

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Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles.

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2015 nî lūn-bûn

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2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

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2015年论文

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Modular Assembly of Allosteric ...... d Feedback-Modulation Handles.

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label

Modular Assembly of Allosteric ...... d Feedback-Modulation Handles.

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prefLabel

Modular Assembly of Allosteric ...... d Feedback-Modulation Handles.

@en

P1476

Modular Assembly of Allosteric ...... d Feedback-Modulation Handles.

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P2093

Arne Scholz

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Florian Pühler

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Gerhard Siemeister

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Ingo V Hartung

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Jens Geisler

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Marion Hitchcock

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Oliver von Ahsen

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Roland Neuhaus

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Roman C Hillig

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P2860

RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer

Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions

Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories

Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

BRAF mutation predicts sensitivity to MEK inhibition

Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.

A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer.

P304

2004-2013

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P31

scholarly article

P356

10.1002/CMDC.201500442

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2015-11-06T00:00:00Z

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P698

26541480

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P921

allosteric inhibitor