Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent
about
Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environmentsMEK and the inhibitors: from bench to bedside.Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approaches.3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response.MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms.Prospects for MEK inhibitors for treating cancer.Type III or allosteric kinase inhibitors for the treatment of non-small cell lung cancer.Molecular recognition in chemical and biological systems.Allosteric modulators of MEK1: drug design and discovery.Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles.Emerging targeted therapies for melanoma.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance.MEK inhibitors under development for treatment of non-small-cell lung cancer.Current Development Status of MEK Inhibitors.Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.Modulation of Plasma Metabolite Biomarkers of the MAPK Pathway with MEK Inhibitor RO4987655: Pharmacodynamic and Predictive Potential in Metastatic Melanoma.Phase I and pharmacokinetics/pharmacodynamics study of the MEK inhibitor RO4987655 in Japanese patients with advanced solid tumors.Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology.A convenient and eco-friendly cerium(III) chloride-catalysed synthesis of methoxime derivatives of aromatic aldehydes and ketones.
P2860
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P2860
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Design and synthesis of novel ...... lly available anticancer agent
@ast
Design and synthesis of novel ...... lly available anticancer agent
@en
Design and synthesis of novel ...... lly available anticancer agent
@nl
type
label
Design and synthesis of novel ...... lly available anticancer agent
@ast
Design and synthesis of novel ...... lly available anticancer agent
@en
Design and synthesis of novel ...... lly available anticancer agent
@nl
prefLabel
Design and synthesis of novel ...... lly available anticancer agent
@ast
Design and synthesis of novel ...... lly available anticancer agent
@en
Design and synthesis of novel ...... lly available anticancer agent
@nl
P2093
P3181
P1476
Design and synthesis of novel ...... lly available anticancer agent
@en
P2093
Charles Belunis
Cheryl Janson
Christine Lukacs
Eisaku Mizuguchi
Hisafumi Okabe
Hitoshi Iikura
Kazuo Hattori
Kohsuke Asoh
Masami Kohchi
Masanori Miwa
P304
P3181
P356
10.1016/J.BMCL.2011.01.062
P407
P577
2011-03-15T00:00:00Z