Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1.
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Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and MetastasisDCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma.DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transitionDoublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cellsDCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinomaRegulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.High expression of the putative cancer stem cell marker, DCLK1, in rectal neuroendocrine tumors.Regulatory Roles of Dclk1 in Epithelial Mesenchymal Transition and Cancer Stem CellsSurvival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase.Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury.Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.Unconventional Functions of Mitotic Kinases in Kidney Tumorigenesis.Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer.(Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression.Functional implication of Dclk1 and Dclk1-expressing cells in cancer.APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases.Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.Targeted kinase inhibition relieves slowness and tremor in a Drosophila model of LRRK2 Parkinson's disease.Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis.DCAMKL1 is associated with the malignant status and poor outcome in bladder cancer.Small-Molecule Inhibitors of LRRK2.Overexpression of DCLK1 is predictive for recurrent disease in major salivary gland malignancies.Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.Association of doublecortin-like kinase 1 with tumor aggressiveness and poor biochemical recurrence-free survival in prostate cancer.
P2860
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P2860
Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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2014年學術文章
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2014年學術文章
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name
Small molecule kinase inhibito ...... of doublecortin-like kinase 1.
@en
type
label
Small molecule kinase inhibito ...... of doublecortin-like kinase 1.
@en
prefLabel
Small molecule kinase inhibito ...... of doublecortin-like kinase 1.
@en
P2093
P2860
P50
P356
P1433
P1476
Small molecule kinase inhibito ...... of doublecortin-like kinase 1
@en
P2093
Courtney W Houchen
Daniel B Owen
Dongfeng Qu
Naushad Ali
Ralf Janknecht
Randal May
P2860
P2888
P356
10.1186/1476-4598-13-103
P577
2014-05-06T00:00:00Z
P5875
P6179
1001909651