Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation. - Wikidata - wikimedia - TriplyDB

Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation.

Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation.

http://www.wikidata.org/entity/Q39101403

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Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin Molecular targets for antiepileptic drug development Mechanisms of the gabapentinoids and α 2 δ-1 calcium channel subunit in neuropathic pain The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders The ß subunit of voltage-gated Ca2+ channels Central Mechanisms Mediating Thrombospondin-4-induced Pain States.Emerging evidence for specific neuronal functions of auxiliary calcium channel α₂δ subunits.Regulation of high-voltage-activated Ca(2+) channel function, trafficking, and membrane stability by auxiliary subunits.Contribution of primary afferent channels to neuropathic pain.Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond.Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat cutaneous DRG neurons Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states.Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin.The upregulation of α2δ-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit.Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes.The effects of intrathecal and systemic gabapentin on spinal substance P release.Nerve injury-induced calcium channel alpha-2-delta-1 protein dysregulation leads to increased pre-synaptic excitatory input into deep dorsal horn neurons and neuropathic allodynia The antiallodynic action of pregabalin in neuropathic pain is independent from the opioid system.Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture.Opioid analgesics increase incidence of somnolence and dizziness as adverse effects of pregabalin: a retrospective study.Spinal 5-HT3 receptors facilitate behavioural hypersensitivity induced by elevated calcium channel alpha-2-delta-1 protein Pregabalin for the treatment of painful neuropathy.Venom peptides as a rich source of cav2.2 channel blockers.Multiplicative interactions to enhance gabapentin to treat neuropathic pain.Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons Fibromyalgia: harmonizing science with clinical practice considerations.The α2δ-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl/6 mice α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology Clinical use of pregabalin in the management of central neuropathic pain Pregabalin in neuropathic pain: evidences and possible mechanisms.Engineering proteins for custom inhibition of Ca(V) channels.Calcium channel α2δ1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis.Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury.

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Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation.

http://www.wikidata.org/entity/Q39101403

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Calcium channel alpha2delta1 s ...... citability in pain modulation.

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Z David Luo

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P2860

Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury

The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels

Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord

Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones

Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia

Multiple neurological abnormalities in mice deficient in the G protein Go

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

The combined effects of N-type calcium channel blockers and morphine on A delta versus C fiber mediated nociception.

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