The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer. - Wikidata - wikimedia - TriplyDB

The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.

The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.

http://www.wikidata.org/entity/Q39286062

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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancers.MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.Lipid degradation promotes prostate cancer cell survival.Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway Characterization of transcriptional changes in ERG rearrangement-positive prostate cancer identifies the regulation of metabolic sensors such as neuropeptide Y.Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia.MELK-a conserved kinase: functions, signaling, cancer, and controversy.Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness.Stathmin involvement in the maternal embryonic leucine zipper kinase pathway in glioblastoma.Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer.Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells.Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines.Genome-wide screen identifies a novel prognostic signature for breast cancer survival.Plakophilins in desmosomal adhesion and signaling.Identification of prognostic markers of high grade prostate cancer through an integrated bioinformatics approach.MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.Maternal embryonic leucine zipper kinase inhibits epithelial-mesenchymal transition by regulating transforming growth factor-β signaling.Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor.EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205.AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment.p53-independent p21 induction by MELK inhibition.The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer.CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials.Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer.Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein.MELK expression correlates with tumor mitotic activity but is not required for cancer growth.Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma.Identification of potential therapeutic targets in prostate cancer through a cross-species approach.Challenges in validating candidate therapeutic targets in cancer.MicroRNA-27a-5p regulation by promoter methylation and MYC signaling in prostate carcinogenesis.MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells.Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK.

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P2860

The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.

http://www.wikidata.org/entity/Q39286062

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

The maternal embryonic leucine ...... in high-grade prostate cancer.

@en

The maternal embryonic leucine zipper kinase

@nl

type

label

The maternal embryonic leucine ...... in high-grade prostate cancer.

@en

The maternal embryonic leucine zipper kinase

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prefLabel

The maternal embryonic leucine ...... in high-grade prostate cancer.

@en

The maternal embryonic leucine zipper kinase

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S00109-012-0949-1

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Journal of Molecular Medicine

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The maternal embryonic leucine ...... in high-grade prostate cancer.

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Eberhard Steiner

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Georg Bartsch

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Georg Schäfer

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Helmut Klocker

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Holger Sültmann

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Jan C Brase

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Jennifer Metzger

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Maria Fälth

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Nicole Chui Pressinotti

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Ruprecht Kuner

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P2860

Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation

lumi: a pipeline for processing Illumina microarray

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

GOstat: find statistically overrepresented Gene Ontologies within a group of genes

Integrative genomic profiling of human prostate cancer

Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression.

Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer.

Prostate-specific antigen testing in Tyrol, Austria: prostate cancer mortality reduction was supported by an update with mortality data up to 2008.

The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection.

Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study.

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2

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