Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis.
about
Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblastsCDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanismsING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylationControl of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cellsInactivation of p53 and life span extension of human diploid fibroblasts by mot-2The role of senescence and immortalization in carcinogenesis.Analysis of ku80-mutant mice and cells with deficient levels of p53Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblastsSenescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci.Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts.Regulation of cellular senescence by p53.Telomeres and telomerase biology in vertebrates: progress towards a non-human model for replicative senescence and ageing.p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.Cellular senescence, an unpopular yet trustworthy tumor suppressor mechanism.Chitosan Treatment Delays the Induction of Senescence in Human Foreskin Fibroblast Strains.Characterization of cellular senescence mechanisms in human corneal endothelial cells.The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes.HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence.Curcumin triggers p16-dependent senescence in active breast cancer-associated fibroblasts and suppresses their paracrine procarcinogenic effectsp16INK4a-induced senescence is disabled by melanoma-associated mutationsSenescence at a glanceWnt-signaling and senescence: A tug of war in early neoplasia?Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes.The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to transactivate microRNA-141 and microRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA damage.Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression.Genetics of melanoma progression: the rise and fall of cell senescence.Mre11 modulates the fidelity of fusion between short telomeres in human cells.Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status.The nature of telomere fusion and a definition of the critical telomere length in human cells.Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression.Cytotoxic action of phorbol esters on human pancreatic cancer cells.Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans.p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway.Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytesSmall molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts.Transcriptional down-regulation of the retinoblastoma protein is associated with differentiation and apoptosis in human colorectal epithelial cells.Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund-Thomson syndrome.Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression.
P2860
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P2860
Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Control of replicative life sp ...... n M1 senescence and M2 crisis.
@en
Control of replicative life sp ...... n M1 senescence and M2 crisis.
@nl
type
label
Control of replicative life sp ...... n M1 senescence and M2 crisis.
@en
Control of replicative life sp ...... n M1 senescence and M2 crisis.
@nl
prefLabel
Control of replicative life sp ...... n M1 senescence and M2 crisis.
@en
Control of replicative life sp ...... n M1 senescence and M2 crisis.
@nl
P2093
P2860
P356
P1476
Control of replicative life sp ...... n M1 senescence and M2 crisis.
@en
P2093
Haughton MF
Wynford-Thomas D
P2860
P304
P356
10.1128/MCB.19.4.3103
P407
P577
1999-04-01T00:00:00Z