about
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalingReplicative senescence induced by Romo1-derived reactive oxygen speciesDNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylationControl of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1p53-dependent ceramide response to genotoxic stressmiR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human agingmiR-17-92 cluster: ups and downs in cancer and agingExtension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressorCellular Senescence:Ex Vivop53-Dependent Asymmetric Cell KineticsHDACs and the senescent phenotype of WI-38 cells.Senescence and the pro-tumorigenic stromaMolecular interactions between telomerase and the tumor suppressor protein p53 in vitroInactivation of p53 and life span extension of human diploid fibroblasts by mot-2PML interaction with p53 and its role in apoptosis and replicative senescencep53 and Bax: putative death factors in taste cell turnoverInduction of p53-dependent p21 limits proliferative activity of rat hepatocytes in the presence of hepatocyte growth factorNEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cellsEarly aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.A reassessment of the telomere hypothesis of senescence.Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cellsAlternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase.Physical and functional interaction between p53 and the Werner's syndrome protein.Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo.ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor.Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblastsRequirement for p27(KIP1) in retinoblastoma protein-mediated senescence.Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence.Role of p14(ARF) in replicative and induced senescence of human fibroblasts.A role for SUV39H1-mediated H3K9 trimethylation in the control of genome stability and senescence in WI38 human diploid lung fibroblastsChromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis.Increased stability of the p16 mRNA with replicative senescenceRegulation of cellular senescence by p53.The essence of senescence.Regulation of transcription factor activity during cellular aging.A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts.Molecular bases of progeroid syndromes.The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.Regulation of senescence in cancer and aging.
P2860
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P2860
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Increased activity of p53 in senescing fibroblasts.
@ast
Increased activity of p53 in senescing fibroblasts.
@en
type
label
Increased activity of p53 in senescing fibroblasts.
@ast
Increased activity of p53 in senescing fibroblasts.
@en
prefLabel
Increased activity of p53 in senescing fibroblasts.
@ast
Increased activity of p53 in senescing fibroblasts.
@en
P2093
P2860
P356
P1476
Increased activity of p53 in senescing fibroblasts.
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.18.8348
P407
P577
1995-08-01T00:00:00Z