A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.
about
Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domainsVRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damageMutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasionInduction of p57(KIP2) expression by p73beta.The C terminus of p53 family proteins is a cell fate determinantMicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6Hsp70 chaperones: cellular functions and molecular mechanismThe transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiationOncogenic Intra-p53 Family Member Interactions in Human CancersMutant p53: Multiple Mechanisms Define Biologic Activity in CancerTumor suppressor p53 and its gain-of-function mutants in cancerInvolvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)Smoking, p53 mutation, and lung cancerStructural evolution of p53, p63, and p73: Implication for heterotetramer formationThe rebel angel: mutant p53 as the driving oncogene in breast cancer.EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-ITwo molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein.Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligaseDifferential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63-family of proteins in replicative senescencep73 as a pharmaceutical target for cancer therapyFunctional interplay between MDM2, p63/p73 and mutant p53Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancerMutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.Two p53 tetramers bind one consensus DNA response elementIdentification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy.Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.Mutant p53 gain-of-function in cancer.Interactions of the p53 protein family in cellular stress response in gastrointestinal tumorsp53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.Targeting of p53-transcriptional dysfunction by conditionally replicating adenovirus is not limited by p53-homologues.Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.The role of mutant p53 in human cancer.p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasisOncomorphic TP53 Mutations in Gynecologic Cancers Lose the Normal Protein:Protein Interactions with the microRNA Microprocessing ComplexHomozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese populationp53 inactivation upregulates p73 expression through E2F-1 mediated transcriptionMolecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.P53: an ubiquitous target of anticancer drugs.
P2860
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P2860
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
A subset of tumor-derived muta ...... tion with the p53 core domain.
@en
A subset of tumor-derived muta ...... tion with the p53 core domain.
@nl
type
label
A subset of tumor-derived muta ...... tion with the p53 core domain.
@en
A subset of tumor-derived muta ...... tion with the p53 core domain.
@nl
prefLabel
A subset of tumor-derived muta ...... tion with the p53 core domain.
@en
A subset of tumor-derived muta ...... tion with the p53 core domain.
@nl
P2093
P2860
P1476
A subset of tumor-derived muta ...... tion with the p53 core domain.
@en
P2093
P2860
P304
P356
10.1128/MCB.21.5.1874-1887.2001
P407
P577
2001-03-01T00:00:00Z