Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals.
about
p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesisRaf family kinases: old dogs have learned new tricksCRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutationsNegative regulation of mitochondrial VDAC channels by C-Raf kinase.Raf-interactome in tuning the complexity and diversity of Raf function.Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell deathIn vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin BBag1 is essential for differentiation and survival of hematopoietic and neuronal cells.Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targetsDysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunitiesThe mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1An old kinase on a new path: Raf and apoptosis.RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins.Upregulated Ras/Raf/ERK1/2 signaling pathway: a new hope in the repair of spinal cord injury.Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.Update on therapy for melanoma: opportunities for patient selection and overcoming tumor resistance.Tumor genotype determines susceptibility to oncolytic herpes simplex virus mutants: strategies for clinical application.Caffeine induces cell death via activation of apoptotic signal and inactivation of survival signal in human osteoblastsContributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.BAD: undertaker by night, candyman by day.Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC.Daunorubicin induces cell death via activation of apoptotic signalling pathway and inactivation of survival pathway in muscle-derived stem cells.Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent mannerERK mediates anti-apoptotic effect through phosphorylation and cytoplasmic localization of p21Waf1/Cip1/Sdi in response to DNA damage in normal human embryonic fibroblast (HEF) cells.Grb10 and active Raf-1 kinase promote Bad-dependent cell survival.Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death.Prevention of TNF-alpha-induced apoptosis in polyamine-depleted IEC-6 cells is mediated through the activation of ERK1/2.Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation.PKC and Raf-1 inhibition-related apoptotic signalling in N2a cells.Activation of STAT5 triggers proliferation and contributes to anti-apoptotic signalling mediated by the oncogenic Xmrk kinase.A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling.The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate.A novel strategy for mechanism based computational drug discovery.Gallic acid downregulates matrix metalloproteinase-2 (MMP-2) and MMP-9 in human leukemia cells with expressed Bcr/Abl.Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling.
P2860
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P2860
Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Apoptosis suppression by Raf-1 ...... ol 3-kinase-dependent signals.
@en
Apoptosis suppression by Raf-1 ...... ol 3-kinase-dependent signals.
@nl
type
label
Apoptosis suppression by Raf-1 ...... ol 3-kinase-dependent signals.
@en
Apoptosis suppression by Raf-1 ...... ol 3-kinase-dependent signals.
@nl
prefLabel
Apoptosis suppression by Raf-1 ...... ol 3-kinase-dependent signals.
@en
Apoptosis suppression by Raf-1 ...... ol 3-kinase-dependent signals.
@nl
P2093
P2860
P1476
Apoptosis suppression by Raf-1 ...... ol 3-kinase-dependent signals.
@en
P2093
A von Gise
B Hemmings
C Wellbrock
F Berberich-Siebelt
J Troppmair
P2860
P304
P356
10.1128/MCB.21.7.2324-2336.2001
P407
P577
2001-04-01T00:00:00Z