The molecular genetics of Philadelphia chromosome-positive leukemias.
about
The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinasesProtein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activationTranscriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinasesThe t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcriptThe (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemiaInvolvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanomaStructural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocationCan, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set geneA DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/MDepletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoformsThe Philadelphia chromosome in leukemogenesisBiosensors in clinical practice: focus on oncohematology.Ponatinib is a pan-BCR-ABL kinase inhibitor: MD simulations and SIE studyChronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responsesIdentification of small molecules that disrupt signaling between ABL and its positive regulator RIN1The molecular basis of genetic dominanceFrom oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents.Coevolution of the domains of cytoplasmic tyrosine kinases.Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.An intramolecular SH3-domain interaction regulates c-Abl activity.Molecular defects associated with the acute phase CML.Oncology.Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy.Cytogenetic clonal evolution alone in CML relapse post-transplantation does not adversely affect response to imatinib mesylate treatment.STAT signaling in the pathogenesis and treatment of cancerThe Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNKSignaling by ABL oncogenes through cyclin D1.bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.It's about time: lessons for solid tumors from chronic myelogenous leukemia therapyExpression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder.The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-AblCirculating heat shock protein 70 and progression in patients with chronic myeloid leukemia.Biology and treatment of adult acute lymphoblastic leukemiaBCR-ABL fusion peptides and cytotoxic T cells in chronic myeloid leukaemia.Cell cycle-related shifts in subcellular localization of BCR: association with mitotic chromosomes and with heterochromatin.
P2860
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P2860
The molecular genetics of Philadelphia chromosome-positive leukemias.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
The molecular genetics of Philadelphia chromosome-positive leukemias.
@en
The molecular genetics of Philadelphia chromosome-positive leukemias.
@nl
type
label
The molecular genetics of Philadelphia chromosome-positive leukemias.
@en
The molecular genetics of Philadelphia chromosome-positive leukemias.
@nl
prefLabel
The molecular genetics of Philadelphia chromosome-positive leukemias.
@en
The molecular genetics of Philadelphia chromosome-positive leukemias.
@nl
P2093
P1476
The molecular genetics of Philadelphia chromosome-positive leukemias.
@en
P2093
Gutterman JU
Kurzrock R
P304
P356
10.1056/NEJM198810133191506
P407
P577
1988-10-01T00:00:00Z