Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor.
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Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHRIdentification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant targetCell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHRPDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma.Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcomaAn engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogeneGenome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT).PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcomaGene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma.Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation.Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy optionsChildhood rhabdomyosarcoma: recent advances and prospective views.The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.Molecular profiling of childhood cancer: Biomarkers and novel therapiescDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene.Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments.Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion.Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.Phosphorylation of serine 205 by the protein kinase CK2 persists on Pax3-FOXO1, but not Pax3, throughout early myogenic differentiation.Molecular and cellular biology of rhabdomyosarcoma.Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects.Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma.Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities.Microarray analysis detects novel Pax3 downstream target genes.The COOH-terminal transactivation domain plays a key role in regulating the in vitro and in vivo function of Pax3 homeodomain.Profiling and functional annotation of mRNA gene expression in pediatric rhabdomyosarcoma and Ewing's sarcoma.JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells.The over-expression of cell migratory genes in alveolar rhabdomyosarcoma could contribute to metastatic spread.Targeting the insulin-like growth factor pathway in rhabdomyosarcomas: rationale and future perspectives.PAX-FKHR function as pangenes by simultaneously inducing and inhibiting myogenesis.Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domainPAX3-FKHR transformation increases 26 S proteasome-dependent degradation of p27Kip1, a potential role for elevated Skp2 expression.Comparative analysis of paired- and homeodomain-specific roles in PAX3-FKHR oncogenesis.A review of soft-tissue sarcomas: translation of biological advances into treatment measures.Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminatesPAX3-FKHR positive and negative tumors
P2860
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P2860
Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Tumor-specific PAX3-FKHR trans ...... growth factor alpha receptor.
@en
Tumor-specific PAX3-FKHR trans ...... growth factor alpha receptor.
@nl
type
label
Tumor-specific PAX3-FKHR trans ...... growth factor alpha receptor.
@en
Tumor-specific PAX3-FKHR trans ...... growth factor alpha receptor.
@nl
prefLabel
Tumor-specific PAX3-FKHR trans ...... growth factor alpha receptor.
@en
Tumor-specific PAX3-FKHR trans ...... growth factor alpha receptor.
@nl
P2093
P2860
P356
P1476
Tumor-specific PAX3-FKHR trans ...... growth factor alpha receptor.
@en
P2093
P2860
P304
P356
10.1128/MCB.18.7.4118
P407
P577
1998-07-01T00:00:00Z