BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.
about
Classification of intrinsically disordered regions and proteinsRegulation of Bim in Health and DiseaseRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisWrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulatorsThe age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogasterInositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signaling.The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanismsRegulating the 20S proteasome ubiquitin-independent degradation pathway.Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2)Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.Curcumin inhibits HIV-1 by promoting Tat protein degradation.The N-terminal domain of Rpn4 serves as a portable ubiquitin-independent degron and is recognized by specific 19S RP subunits.Proteins directly interacting with mammalian 20S proteasomal subunits and ubiquitin-independent proteasomal degradationThe increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability.Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-BControl of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.HIV-1 Rev downregulates Tat expression and viral replication via modulation of NAD(P)H:quinine oxidoreductase 1 (NQO1).NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis.A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions.The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.Oncogenic addiction to high 26S proteasome level.Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates
P2860
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P2860
BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
BIM(EL), an intrinsically diso ...... bsence of poly-ubiquitylation.
@en
BIM(EL), an intrinsically diso ...... bsence of poly-ubiquitylation.
@nl
type
label
BIM(EL), an intrinsically diso ...... bsence of poly-ubiquitylation.
@en
BIM(EL), an intrinsically diso ...... bsence of poly-ubiquitylation.
@nl
prefLabel
BIM(EL), an intrinsically diso ...... bsence of poly-ubiquitylation.
@en
BIM(EL), an intrinsically diso ...... bsence of poly-ubiquitylation.
@nl
P2093
P50
P356
P1476
BIM(EL), an intrinsically diso ...... absence of poly-ubiquitylation
@en
P2093
Ceri M Wiggins
Claire L Joyce
David Komander
Mark Johnson
Simon J Cook
Yosef Shaul
P304
P356
10.1242/JCS.058438
P407
P577
2011-03-01T00:00:00Z