A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).

A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).

Item
http://www.wikidata.org/entity/Q42708880
Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsThe Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiationRole of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cellsBafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways.Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancer.DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome.Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway.Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid.A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy.Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells.MuvB: A Key to Cell Cycle Control in Ovarian Cancer.
P2860

A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).

Item
http://www.wikidata.org/entity/Q42708880
description
2014 nî lūn-bûn
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2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
A novel DYRK1B inhibitor AZ191 ...... D1 at Thr(286), not Thr(288).
@en
A novel DYRK1B inhibitor AZ191 ...... D1 at Thr(286), not Thr(288).
@nl
type
label
A novel DYRK1B inhibitor AZ191 ...... D1 at Thr(286), not Thr(288).
@en
A novel DYRK1B inhibitor AZ191 ...... D1 at Thr(286), not Thr(288).
@nl
prefLabel
A novel DYRK1B inhibitor AZ191 ...... D1 at Thr(286), not Thr(288).
@en
A novel DYRK1B inhibitor AZ191 ...... D1 at Thr(286), not Thr(288).
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P356
P1433
P1476
A novel DYRK1B inhibitor AZ191 ...... n D1 at Thr(286), not Thr(288)
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921