The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.
about
Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapyMaintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complexThe site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivationLent-On-Plus Lentiviral vectors for conditional expression in human stem cellsTherapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patientsShielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cellsIntegrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitroIncorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrantsThe 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity.A functional screen for regulatory elements that improve retroviral vector gene expressionGenomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element.Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3'LTR.Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities.The beta-globin locus control region versus gene therapy vectors: a struggle for expression.Silencing of gene expression: implications for design of retrovirus vectors.Delivery of novel macromolecular drugs against HIV-1.The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells.Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell-based gene therapy.CpG island protects Rous sarcoma virus-derived vectors integrated into nonpermissive cells from DNA methylation and transcriptional suppressionOccurrence of leukaemia following gene therapy of X-linked SCID.A chromatin insulator protects retrovirus vectors from chromosomal position effects.Current advances in retroviral gene therapy.Lentiviral Vectors Mediate Long-Term and High Efficiency Transgene Expression in HEK 293T cells.An insulator element located at the cyclin B1 interacting protein 1 gene locus is highly conserved among mammalian species.Strategies to insulate lentiviral vector-expressed transgenesPrototypic chromatin insulator cHS4 protects retroviral transgene from silencing in Schistosoma mansoniGlobin gene transfer as a potential treatment for the beta-thalassaemias and sickle cell disease.Methods for gene transfer to the central nervous system.Retrovirus silencer blocking by the cHS4 insulator is CTCF independent.Versatility of gene therapy vectors through viruses.Stable gammaretroviral vector expression during embryonic stem cell-derived in vitro hematopoietic development.Reducing the genotoxic potential of retroviral vectors.Gene therapy for hemoglobinopathies: progress and challenges.Viral vectors: from virology to transgene expressionOverview: engineering transgenic constructs and mice.A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells.Supplying clotting factors from hematopoietic stem cell-derived erythroid and megakaryocytic lineage cells.Human matrix attachment regions are necessary for the establishment but not the maintenance of transgene insulation in Drosophila melanogasterGene therapy for β-thalassaemia: the continuing challenge.
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P2860
The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
The cHS4 insulator increases t ...... chromosomal integration sites.
@en
The cHS4 insulator increases t ...... chromosomal integration sites.
@nl
type
label
The cHS4 insulator increases t ...... chromosomal integration sites.
@en
The cHS4 insulator increases t ...... chromosomal integration sites.
@nl
prefLabel
The cHS4 insulator increases t ...... chromosomal integration sites.
@en
The cHS4 insulator increases t ...... chromosomal integration sites.
@nl
P2093
P2860
P1433
P1476
The cHS4 insulator increases t ...... chromosomal integration sites
@en
P2093
P2860
P304
P356
10.1128/JVI.74.10.4679-4687.2000
P407
P577
2000-05-01T00:00:00Z