Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation - Wikidata - wikimedia - TriplyDB

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

http://www.wikidata.org/entity/Q39646963

about

The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane Pharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant Proteins Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor Phosphorylation-independent desensitization of GABA(B) receptor by GRK4 Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened Functional modulation of human delta opioid receptor by neuropeptide FF.Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors Pharmacological chaperoning: a primer on mechanism and pharmacology Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2 Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.Systematic and quantitative analysis of G protein-coupled receptor trafficking motifs.Importance of extracellular loop one of the neuropeptide S receptor for biogenesis and function Using pharmacological chaperones to restore proteostasis A plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana.Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retention Chaperoning G protein-coupled receptors: from cell biology to therapeutics Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.GnRH signaling, the gonadotrope and endocrine control of fertility.Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor Human beta1-adrenergic receptor is subject to constitutive and regulated N-terminal cleavage GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptors The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors.Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease.Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions.Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist Can intellectualism stifle scientific discovery?Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)Recent advances on the δ opioid receptor: from trafficking to function.Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance.Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.Chemical chaperones--a new concept in drug research.

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P2860

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

http://www.wikidata.org/entity/Q39646963

description

2002 nî lūn-bûn

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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2002年论文

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2002年论文

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name

Ligands act as pharmacological ...... lta opioid receptor maturation

@en

Ligands act as pharmacological ...... ta opioid receptor maturation.

@nl

type

label

Ligands act as pharmacological ...... lta opioid receptor maturation

@en

Ligands act as pharmacological ...... ta opioid receptor maturation.

@nl

prefLabel

Ligands act as pharmacological ...... lta opioid receptor maturation

@en

Ligands act as pharmacological ...... ta opioid receptor maturation.

@nl

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The EMBO Journal

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Ligands act as pharmacological ...... lta opioid receptor maturation

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P2093

André Laperrière

http://www.w3.org/2001/XMLSchema#string

Jean-Pierre Morello

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Mireille Hogue

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Suparna Bhalla

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Ulla E Petäjä-Repo

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P2860

Crystal structure of rhodopsin: A G protein-coupled receptor

High-efficiency transformation of mammalian cells by plasmid DNA

Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

The delta-opioid receptor: molecular pharmacology, signal transduction, and the determination of drug efficacy

Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein

Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER

Setting the standards: quality control in the secretory pathway

Proper folding and endoplasmic reticulum to golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine.

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11437007

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11927547

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molecular chaperones

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125943

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