Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals.
about
A functional analysis of the spacer of V(D)J recombination signal sequencesStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Recombination-activating gene proteins: more regulation, pleaseHigh mobility group protein B1 enhances DNA repair and chromatin modification after DNA damageThermal dependency of RAG1 self-association properties.HMGB1: roles in base excision repair and related function.HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.The DNA architectural protein HMGB1 displays two distinct modes of action that promote enhanceosome assembly.A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals.RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.HMGB1 in health and disease.Identification and characterization of a gain-of-function RAG-1 mutant.Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksSequence variation in the human T-cell receptor loci.The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes.Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction.The bounty of RAGs: recombination signal complexes and reaction outcomes.The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination.Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.Quantitative analyses of RAG-RSS interactions and conformations revealed by atomic force microscopy.Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.Molecular mechanism underlying RAG1/RAG2 synaptic complex formation.Real-time analysis of RAG complex activity in V(D)J recombinationSynapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination.Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer.Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis.Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination.Early intermediates of mariner transposition: catalysis without synapsis of the transposon ends suggests a novel architecture of the synaptic complexBoth high mobility group (HMG)-boxes and the acidic tail of HMGB1 regulate recombination-activating gene (RAG)-mediated recombination signal synapsis and cleavage in vitro.Reassignment of the murine 3'TRDD1 recombination signal sequence.Determinants of HMGB proteins required to promote RAG1/2-recombination signal sequence complex assembly and catalysis during V(D)J recombination.Physiological Roles of DNA Double-Strand Breaks.
P2860
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P2860
Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Fine structure and activity of discrete RAG-HMG complexes on V
@nl
Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals.
@en
type
label
Fine structure and activity of discrete RAG-HMG complexes on V
@nl
Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals.
@en
prefLabel
Fine structure and activity of discrete RAG-HMG complexes on V
@nl
Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals.
@en
P2860
P1476
Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals.
@en
P2093
Patrick C Swanson
P2860
P304
P356
10.1128/MCB.22.5.1340-1351.2002
P407
P577
2002-03-01T00:00:00Z