A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown. - Wikidata - wikimedia - TriplyDB

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

http://www.wikidata.org/entity/Q39726890

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Promiscuous DNA synthesis by human DNA polymerase θ DNA polymerase θ (POLQ), double-strand break repair, and cancer DNA Polymerase θ: A Unique Multifunctional End-Joining Machine A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers Mechanism of suppression of chromosomal instability by DNA polymerase POLQ A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer Overexpression of POLQ confers a poor prognosis in early breast cancer patients.Molecular radiobiology: the state of the art A bioinformatics filtering strategy for identifying radiation response biomarker candidates.Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.The therapeutic ratio is preserved for radiotherapy or cisplatin treatment in BRCA2-mutated prostate cancers POLQ in breast cancer.Human DNA polymerase θ grasps the primer terminus to mediate DNA repair Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma.Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis Dilemmas concerning dose distribution and the influence of relative biological effect in proton beam therapy of medulloblastoma Linking DNA polymerase theta structure and function in health and disease DNA polymerase POLQ and cellular defense against DNA damage.Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials.DNA polymerases and cancer.DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides Base excision repair targets for cancer therapy Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.Gamma histone 2AX (γ-H2AX)as a predictive tool in radiation oncology.Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival.Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells.Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases.A role for DNA polymerase θ in the timing of DNA replication.Combinatorial therapeutic approaches with RNAi and anticancer drugs using nanodrug delivery systems.Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells.Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.Depletion of signal recognition particle 72kDa increases radiosensitivity.Expression and Structural Analyses of Human DNA Polymerase θ (POLQ).Characterization of DNA repair deficient strains of Chlamydomonas reinhardtii generated by insertional mutagenesis.The cytotoxic effect of β-elemene against malignant glioma is enhanced by base-excision repair inhibitor methoxyamine.The Future of Radiobiology.

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P2860

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

http://www.wikidata.org/entity/Q39726890

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

A small interfering RNA screen ...... nsitization by POLQ knockdown.

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A small interfering RNA screen ...... nsitization by POLQ knockdown.

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type

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A small interfering RNA screen ...... nsitization by POLQ knockdown.

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A small interfering RNA screen ...... nsitization by POLQ knockdown.

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A small interfering RNA screen ...... nsitization by POLQ knockdown.

@en

A small interfering RNA screen ...... nsitization by POLQ knockdown.

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0008-5472.CAN-09-4040

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Cancer Research

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A small interfering RNA screen ...... nsitization by POLQ knockdown.

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P2093

Eric J Bernhard

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Geoff S Higgins

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Ian D Hickson

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Michio Yoshimura

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Remko Prevo

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Ruth J Muschel

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Steve Taylor

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W Gillies McKenna

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Yin-Fai Lee

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P2860

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

High-efficiency bypass of DNA damage by human DNA polymerase Q

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

A loss of function screen identifies nine new radiation susceptibility genes.

Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.

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2984-2993

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7

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70

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Thomas Helleday

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2010-03-16T00:00:00Z

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20233878

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2848966

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