Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. - Wikidata - wikimedia - TriplyDB

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

http://www.wikidata.org/entity/Q39738488

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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish.Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.Insulin-like growth factor 1 physiology: lessons from mouse models.Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?SH2B1 regulation of energy balance, body weight, and glucose metabolism.The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes.Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.Insulin resistance and pancreatic beta cell failure Pancreatic beta-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency.Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination.Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.The insulin-like growth factor system: towards clinical applications.When the usual insulin is just not enough Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance Transgenic rescue of insulin receptor-deficient mice Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis Pitfalls of PCR-based strategy for genotyping cre-loxP mice Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.Formation and regeneration of the endocrine pancreas.Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetes Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop Growth factor control of pancreatic islet regeneration and function The role of liver-derived insulin-like growth factor-I.SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion.DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet.IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling.Modulation of β-cell function: a translational journey from the bench to the bedside.Insulin and GH-IGF-I axis: endocrine pacer or endocrine disruptor?Role of CCN5 (WNT1 inducible signaling pathway protein 2) in pancreatic islets.

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P2860

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

http://www.wikidata.org/entity/Q39738488

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

@en

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

@nl

type

label

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

@en

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

@nl

prefLabel

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

@en

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

@nl

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P1433

Journal of Clinical Investigation

P1476

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

@en

P2093

Jun Nakae

http://www.w3.org/2001/XMLSchema#string

Manrico Morroni

http://www.w3.org/2001/XMLSchema#string

Morris F White

http://www.w3.org/2001/XMLSchema#string

Pedro L Herrera

http://www.w3.org/2001/XMLSchema#string

Peter E Fisher

http://www.w3.org/2001/XMLSchema#string

Saverio Cinti

http://www.w3.org/2001/XMLSchema#string

Shouhong Xuan

http://www.w3.org/2001/XMLSchema#string

Tadahiro Kitamura

http://www.w3.org/2001/XMLSchema#string

Yoshiaki Kido

http://www.w3.org/2001/XMLSchema#string

P2860

Disruption of IRS-2 causes type 2 diabetes in mice

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.

IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.

Perspective: Postnatal pancreatic beta cell growth.

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1011-1019

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scholarly article

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10.1172/JCI0215276

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7

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110

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Domenico Accili

Katerina Politi

Argiris Efstratiadis

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2002-10-01T00:00:00Z

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12370279

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151144

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