Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.
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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALSRedox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linkingTDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNAhCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complexTARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear importMatrin3: connecting gene expression with the nuclear matrixAlterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisThe function of RNA-binding proteins at the synapse: implications for neurodegenerationMitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?Does a loss of TDP-43 function cause neurodegeneration?Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregationPub1p C-Terminal RRM Domain Interacts with Tif4631p through a Conserved Region Neighbouring the Pab1p Binding SiteTDP-43 aggregation in neurodegeneration: are stress granules the key?A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseIdentification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexesTDP-43 identified from a genome wide RNAi screen for SOD1 regulatorsThe ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrityKinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.Astrocytic TDP-43 pathology in Alexander diseaseMitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesQuantitative analysis of cryptic splicing associated with TDP-43 depletion.Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismTDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organizationDrosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLSBiomarkers in frontotemporal lobar degenerations--progress and challenges.TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.RNA granule assembly and disassembly modulated by nuclear factor associated with double-stranded RNA 2 and nuclear factor 45ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.Fragile hearts: new insights into translational control in cardiac muscle.TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.
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Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Global analysis of TDP-43 inte ...... ing and translation machinery.
@en
Global analysis of TDP-43 inte ...... ing and translation machinery.
@nl
type
label
Global analysis of TDP-43 inte ...... ing and translation machinery.
@en
Global analysis of TDP-43 inte ...... ing and translation machinery.
@nl
prefLabel
Global analysis of TDP-43 inte ...... ing and translation machinery.
@en
Global analysis of TDP-43 inte ...... ing and translation machinery.
@nl
P2093
P2860
P356
P1476
Global analysis of TDP-43 inte ...... cing and translation machinery
@en
P2093
Anthony A High
Brian D Freibaum
Raghu K Chitta
P2860
P304
P356
10.1021/PR901076Y
P577
2010-02-01T00:00:00Z