Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.

Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.

Item
http://www.wikidata.org/entity/Q39792717
The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139Identifying ligands at orphan GPCRs: current status using structure-based approaches.Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.Synthesis and Antiviral Bioassay of New Diphenyl Ether-based Compounds.The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity.Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor.Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.
P2860

Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.

Item
http://www.wikidata.org/entity/Q39792717
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.
@en
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.
@nl
type
label
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.
@en
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.
@nl
prefLabel
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.
@en
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P921
P932
P356
P1433
P1476
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P921
P932