about
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effectorItraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonistsDifferential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date reviewTargeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsAdvanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitorsNovel agents for advanced pancreatic cancerNot so Fast: Co-Requirements for Sonic Hedgehog Induced Brain TumorigenesisTargeted therapy for orbital and periocular basal cell carcinoma and squamous cell carcinomaHedgehog signaling pathway and its targets for treatment in basal cell carcinomaDefinition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palateStructure and function of the Smoothened extracellular domain in vertebrate Hedgehog signalingStructural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signallingStructural basis for Smoothened receptor modulation and chemoresistance to anticancer drugsStructural basis of Smoothened regulation by its extracellular domainsG-protein coupled receptor expression patterns delineate medulloblastoma subgroupsA novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse modelArsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulationSmoothened goes molecular: new pieces in the hedgehog signaling puzzleEffects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer.Advanced treatment for basal cell carcinomas.Effects of the Hedgehog pathway inhibitor GDC-0449 on lung cancer cell lines are mediated by side populations.Genetics and epigenetics of the skin meet deep sequence.Targeting Hedgehog--a cancer stem cell pathwayVismodegib: in locally advanced or metastatic basal cell carcinoma.Experimental approaches for the treatment of malignant gliomas.Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumorsFrequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Medicinal history of North American Veratrum.Tackling the cancer stem cells - what challenges do they pose?Discovery of small-molecule modulators of the Sonic Hedgehog pathway.Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostateVismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste budsUp-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication.An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibitionQuiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastomaSynthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor βA Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
GDC-0449-a potent inhibitor of the hedgehog pathway.
@en
GDC-0449-a potent inhibitor of the hedgehog pathway.
@nl
type
label
GDC-0449-a potent inhibitor of the hedgehog pathway.
@en
GDC-0449-a potent inhibitor of the hedgehog pathway.
@nl
prefLabel
GDC-0449-a potent inhibitor of the hedgehog pathway.
@en
GDC-0449-a potent inhibitor of the hedgehog pathway.
@nl
P2093
P1476
GDC-0449-a potent inhibitor of the hedgehog pathway.
@en
P2093
Changgeng Qian
Cyrus Khojasteh
Daniel P Sutherlin
Derek Marshall
Georgette M Castanedo
James C Marsters
Janet L Gunzner
Jason Halladay
John H A Stibbard
P304
P356
10.1016/J.BMCL.2009.08.049
P407
P577
2009-08-15T00:00:00Z