Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma - Wikidata - wikimedia - TriplyDB

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

http://www.wikidata.org/entity/Q39885220

about

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma Pancreatic Cancer from Molecular Pathways to Treatment Opinion Pancreatic cancer from bench to bedside: molecular pathways and treatment options State of the art biological therapies in pancreatic cancer GEMMs as preclinical models for testing pancreatic cancer therapies Molecular Targeted Intervention for Pancreatic Cancer Genetically engineered mouse models of pancreatic adenocarcinoma From fly wings to targeted cancer therapies: a centennial for notch signaling Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells.Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward.Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression.Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells are inhibited by γ-secretase inhibitor IX.Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma The pathological significance of Notch1 in oral squamous cell carcinoma.Role of Notch and its oncogenic signaling crosstalk in breast cancer.DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis.A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma Notch signaling proteins: legitimate targets for cancer therapy.Overcoming drug resistance in pancreatic cancer.NOTCH pathway inactivation promotes bladder cancer progression The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells.KRAS Mouse Models: Modeling Cancer Harboring KRAS Mutations.MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma.Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism.3,5-bis(2,4-difluorobenzylidene)-4-piperidone, a novel compound that affects pancreatic cancer growth and angiogenesis Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice.Deploying mouse models of pancreatic cancer for chemoprevention studies Aberrant signaling pathways in pancreatic cancer: a two compartment view.Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma Blockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells.Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.Study human pancreatic cancer in mice: how close are they?EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

P2860

Q24627664-2455BDE0-3145-43CE-BB58-8E6F50610399 Q26743482-923574C4-7C1E-40D6-902F-3A5013E5F177 Q26747524-C1D0E7C9-A8A0-478B-BC58-5B1CCD8B5252 Q26769941-97752588-0190-4823-8F0B-218202688275 Q26781848-69DA0583-5B3B-4FC6-86FF-00633A738C1B Q26798453-997CF800-F755-43BB-8620-0A78ABE47475 Q27002973-444137C1-AC72-4133-AD5B-39BBC4E33CE9 Q27004534-0DE91D04-DCA8-4433-9605-95EEE8BFFF19 Q28468696-EEBCCB13-A201-480B-800C-75687E9E43CF Q28478427-0D0028DF-6B05-4D7C-88E1-3ACDC4CBC024 Q28480889-3CF78780-0909-4177-BE5F-1BA3E7D59B2E Q30493254-E5F418D7-1C81-446C-811B-3D2256ECAC76 Q33624574-C0DBF7FF-96D0-47A4-B749-F44FF18D2D58 Q33718581-ADB24090-7976-4333-9EEA-AE6FD3E5C9D4 Q34068002-EE9F8988-3337-413E-ADC5-8914E20958ED Q34201623-47AF1755-3152-41DA-929B-93320BC7F267 Q34456195-9D1FBD69-F993-4F46-AC1A-D6FD7E457B94 Q34533078-EF407C5C-DB7E-4E64-8ADD-B8AEC54CC20A Q34655317-DDAFBD8E-D1C8-4A5C-A3DA-A59B63915CD3 Q34697373-59370F74-C5C7-49BF-A5BE-110EDD174E40 Q34773102-49202B92-3812-4B6B-8A31-D257F969465B Q34895297-C935FD40-676C-4D9F-8F5C-7ABEE0ACFFE6 Q34938155-58B592E9-0D55-4007-BBCB-DCC24490D08F Q34982347-9A35AA8F-0F49-4098-BA5F-DA3733A32F71 Q35036615-1CC82A58-431D-42AD-A427-E354DB5D9918 Q35056671-FA85D752-49CE-404F-BACD-B09B9F1BAD72 Q35083157-B90D77AD-3A59-4A9E-AF45-83BC65C2D519 Q35083740-2CF1B6B4-6D5E-40EA-82B1-231B2544F76E Q35256272-7792B1A8-C584-402F-97D0-9068E29C3303 Q35439618-9F79B9D4-9CF8-48C7-88A9-1D724CFDEC04 Q35541678-A9DABC40-4744-48B6-BBD8-CB873CCC3E60 Q35578568-79A133E2-5D27-4FAE-9EE9-907578683153 Q35622126-85E3BC71-024D-49A5-B01F-C193855B7593 Q35660658-3D48BF0C-C494-45B1-AD41-E11D5B16B7B9 Q35754181-CAE89F66-F69F-48D0-8E02-9E82B9942311 Q35825974-3FC94D8E-F57F-43F7-B8DA-D20086FBA348 Q35891112-34D8860F-B686-47A8-82E8-496BC7AB3CF6 Q36024533-59864254-798F-4A93-84BC-A09A43BD976A Q36511937-298FD8BD-3455-4EC9-9D93-8FA52C630BB6 Q36696146-54C0E6D8-068E-4158-9372-B1CC86D7F7E4

P2860

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

http://www.wikidata.org/entity/Q39885220

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

Inhibition of gamma-secretase ...... ncreatic ductal adenocarcinoma

@en

Inhibition of gamma-secretase ...... creatic ductal adenocarcinoma.

@nl

type

label

Inhibition of gamma-secretase ...... ncreatic ductal adenocarcinoma

@en

Inhibition of gamma-secretase ...... creatic ductal adenocarcinoma.

@nl

prefLabel

Inhibition of gamma-secretase ...... ncreatic ductal adenocarcinoma

@en

Inhibition of gamma-secretase ...... creatic ductal adenocarcinoma.

@nl

P1433

Q39885220-21EFEF8B-9652-4E18-BA3C-6A60691440E9

P1476

Q39885220-58134E5F-F467-4B13-86A7-716C94B53044

P2093

Q39885220-1CF7471C-5775-4C8B-89BA-3676494BB7AD

Q39885220-26425E35-5CFD-4DBA-940D-CBD006728B34

Q39885220-420AE638-23E8-4BDE-93B1-8FF6F6B002DD

Q39885220-45A25D74-E6C2-4246-B153-17025DE5E1BC

Q39885220-4D155769-AC83-467D-A5B1-725381D21FED

Q39885220-66CF8CBD-B321-4805-8285-4658910C3512

Q39885220-81FFA61B-9B14-45AA-8D36-5188F7F06327

Q39885220-834EB3A4-821E-45F7-A5FB-77B35088CC5A

Q39885220-84AC5798-BB45-4FE4-8FE8-AD0684061B8B

Q39885220-9C9657E4-2CA1-4E4B-BFC0-19C5A5E34C76

P2860

Q39885220-054C7BCA-E62B-4066-9988-DAFAAE06CFD1

Q39885220-054D361E-FF9D-4EA5-BD43-0523D45DC1BC

Q39885220-0B3AB764-95D2-42E1-95F5-8FE390B5D24B

Q39885220-122C312F-E008-4CCB-AFA6-AD4878439687

Q39885220-1A687EF9-A28F-428C-AFDF-12EE027237EF

Q39885220-1B8D9E90-9D23-4260-B5F5-F433DCAEBD60

Q39885220-32665DEB-7F4E-48C0-BBBC-488540B08A33

Q39885220-358C08F7-8EF8-4DAC-9DE9-61F573891503

Q39885220-4FBDBFE2-00B3-4DDC-986E-DC22ABC0A4FD

Q39885220-5100F658-5F5F-4328-A41C-303E8042938C

P304

Q39885220-67315B0A-522F-474A-8CE6-809FB34CD876

P31

Q39885220-1DBEA5FB-CE0B-49EC-9BC4-C9A9FEFE50B3

P356

Q39885220-14C89592-B821-4DF0-AB0A-BC12E961313E

P407

Q39885220-410A7478-A194-4229-809C-3EA3EED5B012

P433

Q39885220-1E746F9F-6DDA-484E-8AEF-9E67BDC1438B

P478

Q39885220-F69326D0-E12A-40D7-AB12-7BB52BE871F9

P50

Q39885220-D34F3FC3-4D50-4C8B-A68C-68459E0D7E78

P577

Q39885220-C6A7B796-A0F1-46C5-85C7-169B4281CA70

P5875

Q39885220-2462EE86-5BD0-4CA5-8C32-B6322D8CA9C2

P698

Q39885220-BAC76CB4-3E4E-4793-B8F1-D69E734D5DEE

P921

Q39885220-1E1233AA-74DF-4226-85E7-28B79AD45A6A

P932

Q39885220-F6468B7F-E588-4F48-B534-EF9BAD2E1B86

P356

J.GASTRO.2009.01.008

P1433

Gastroenterology

P1476

Inhibition of gamma-secretase ...... ncreatic ductal adenocarcinoma

@en

P2093

Andrew D Rhim

http://www.w3.org/2001/XMLSchema#string

Aram F Hezel

http://www.w3.org/2001/XMLSchema#string

Ben Z Stanger

http://www.w3.org/2001/XMLSchema#string

Candia Kenific

http://www.w3.org/2001/XMLSchema#string

Daniel Abravanel

http://www.w3.org/2001/XMLSchema#string

Jeffrey Settleman

http://www.w3.org/2001/XMLSchema#string

Ji-Sun Park

http://www.w3.org/2001/XMLSchema#string

Nabeel Bardeesy

http://www.w3.org/2001/XMLSchema#string

Pradip K Majumder

http://www.w3.org/2001/XMLSchema#string

Ruben Plentz

http://www.w3.org/2001/XMLSchema#string

P2860

Notch signaling controls multiple steps of pancreatic differentiation

Cancer statistics, 2008

Notch signaling: cell fate control and signal integration in development

Notch signalling controls pancreatic cell differentiation

Direct regulation of intestinal fate by Notch

Control of endodermal endocrine development by Hes-1

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

P304

1741-9.e6

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1053/J.GASTRO.2009.01.008

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

136

http://www.w3.org/2001/XMLSchema#string

P50

Nabeel Bardeesy

P577

2009-01-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23998763

http://www.w3.org/2001/XMLSchema#string

P698

19208345

http://www.w3.org/2001/XMLSchema#string

P921

P932

3675892

http://www.w3.org/2001/XMLSchema#string