about
Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorPathogenesis of ataxia-telangiectasia: the next generation of ATM functionsInhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingEffects of acute versus chronic hypoxia on DNA damage responses and genomic instability.Perspectives in cell cycle regulation: lessons from an anoxic vertebrate.Crosstalk between the DNA damage response, histone modifications and neovascularisation.Role of senescence and mitotic catastrophe in cancer therapy.Cardiac Cell Senescence and Redox Signaling.A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replicationContextual synthetic lethality of cancer cell kill based on the tumor microenvironment.ATM signalling and cancer.mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesisActivation of DNA damage response signaling by condensed chromatin.Tumor hypoxia and genetic alterations in sporadic cancers.Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.Tug of war between survival and death: exploring ATM function in cancer.Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activationMolecular damage in cancer: an argument for mTOR-driven agingHypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKTATM kinase is activated by sindbis viral vector infection.The emerging role of nuclear architecture in DNA repair and genome maintenance.Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroidsMicroRNAs in the imprinted DLK1-DIO3 region repress the epithelial-to-mesenchymal transition by targeting the TWIST1 protein signaling networkDNA damage, chromatin, and transcription: the trinity of aging.Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1.The Eyes Absent Proteins in Developmental and Pathological Angiogenesis.Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.Microscopic imaging of DNA repair foci in irradiated normal tissues.A possible crosstalk between DNA repair pathways and angiogenesis.Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury.Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization.Targeting hypoxic cells through the DNA damage response.Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences.The ATM protein kinase and cellular redox signaling: beyond the DNA damage response.Controversial aspects of oncogene-induced senescence.Tumor hypoxia as a driving force in genetic instability.Apoptotic cell death under hypoxia.H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
ATM activation and signaling under hypoxic conditions.
@en
ATM activation and signaling under hypoxic conditions.
@nl
type
label
ATM activation and signaling under hypoxic conditions.
@en
ATM activation and signaling under hypoxic conditions.
@nl
prefLabel
ATM activation and signaling under hypoxic conditions.
@en
ATM activation and signaling under hypoxic conditions.
@nl
P2093
P2860
P356
P1476
ATM activation and signaling under hypoxic conditions
@en
P2093
Amato J Giaccia
Ester M Hammond
Muriel R Kaufmann
Philip S Lecane
Zuzana Bencokova
P2860
P304
P356
10.1128/MCB.01301-08
P407
P577
2008-11-03T00:00:00Z