The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway - Wikidata - wikimedia - TriplyDB

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

http://www.wikidata.org/entity/Q39930668

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Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR State of the science: an update on renal cell carcinoma A polycystin-centric view of cyst formation and disease: the polycystins revisited The Cilium: Cellular Antenna and Central Processing Unit Left-right asymmetry in the light of TOR: An update on what we know so far Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila.Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: an open-label randomized controlled pilot study.Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells.Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathway Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.Clinically relevant imaging in tuberous sclerosis.Insight into response to mTOR inhibition when PKD1 and TSC2 are mutated Rabin8 Protein Interacts with GTPase Rheb and Inhibits Phosphorylation of Ser235/Ser236 in Small Ribosomal Subunit Protein S6.Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.Lymphangioleiomyomatosis - a wolf in sheep's clothing.Cystic kidney diseases: many ways to form a cyst.Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia Primary cilia and kidney injury: current research status and future perspectives Emerging evidence of a link between the polycystins and the mTOR pathways.Tuberous sclerosis complex, mTOR, and the kidney: report of an NIDDK-sponsored workshop.Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases.Calcium-mediated mechanisms of cystic expansion.Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications.Birt-Hogg-Dubé syndrome and the skin.The ciliary flow sensor and polycystic kidney disease.The importance of a single primary cilium.Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.Birt-Hogg-Dube syndrome is a novel ciliopathy.Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers Genetic Syndromes Affecting Kidney Development.Primary Cilia in Cystic Kidney Disease.Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue.Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis.

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P2860

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

http://www.wikidata.org/entity/Q39930668

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

The tuberous sclerosis protein ...... lycystin 1-independent pathway

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The tuberous sclerosis protein ...... ycystin 1-independent pathway.

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type

label

The tuberous sclerosis protein ...... lycystin 1-independent pathway

@en

The tuberous sclerosis protein ...... ycystin 1-independent pathway.

@nl

prefLabel

The tuberous sclerosis protein ...... lycystin 1-independent pathway

@en

The tuberous sclerosis protein ...... ycystin 1-independent pathway.

@nl

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P1433

Human Molecular Genetics

P1476

The tuberous sclerosis protein ...... lycystin 1-independent pathway

@en

P2093

Dongyan Liu

http://www.w3.org/2001/XMLSchema#string

Elizabeth P Henske

http://www.w3.org/2001/XMLSchema#string

Jack T Zilfou

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Tasha Morrison

http://www.w3.org/2001/XMLSchema#string

Terry Watnick

http://www.w3.org/2001/XMLSchema#string

Tiffiney R Hartman

http://www.w3.org/2001/XMLSchema#string

Victoria Robb

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle

Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles

Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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151-163

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scholarly article

P356

10.1093/HMG/DDN325

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1

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18

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2008-10-09T00:00:00Z

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23310001

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18845692

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2644647

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